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Table 2 Pathologic characteristics of primary carcinoid tumor arising within mature teratoma of the kidney

From: Primary carcinoid tumor arising within mature teratoma of the kidney: report of a rare entity and review of the literature

Source, year

Macroscopic findings

Components of Mature Teratoma

Architectural patterns of carcinoid tumor

Cytologic features of carcinoid tumor

Mitotic rate of carcinoid tumor*

Immuno-phenotype of carcinoid tumor*

 

Side/Gross

Site/Size, cm

     

Kojiro et al, 1976 [2]

Left/Polycystic with smooth and nodular external surface

NP/17

Mucous secretory glands, columnar epithelium, mature hyaline cartilage, smooth muscle

NP

Finely granular eosinophilic cytoplasm, uniform rounded nuclei with coarse chromatin and small nucleoli

0/10 HPF

NP

Fetissof et al, 1984 [3]

Right/Dilated sac filled with purulent exudate in horseshoe kidney with lower poles connected by broad isthmus

NP/2

Transitional and mucinous columnar epithelium with occasional cilia, smooth muscle, ossified chondroid plaques, nerve bundles with ganglion cells

Anastomosing ribbons intermixed with solid nests

NP

NP

SER+, GLU+, SOM+, ACTH-, CAL-, GAS-, INS-, MOT-, NEU-

Lodding et al, 1997 [1]

Right/Gray-white firm nodule in horseshoe kidney with broad connecting bridge in midline

Lower pole/2

Mature bone

Organoid

Uniform cells

NP

PCK+, NSE+, CHR+, SYN+, S-100+, SER+, PSA-

Yoo et al, 2002 [4]

Left/Well circumscribed, tan-pink, glistening, focally hemorrhagic, primarily solid

Lower pole/3.5

Mucinous tall columnar epithelium, mature smooth muscle, mature bone

Anastomosing ribbons intermixed with solid nests

Monotonous small cells with finely stippled chromatin and inconspicuous nucleoli

0/10 HPF

PCK+, NSE+, CHR+

Kim et al, 2004 [5]

Right/Well defined solid, yellowish tan

Upper and mid poles/3.5

Mucinous columnar and pseudostratified columnar epithelium with occasional cilia, mature bone

Trabecular and anastomosing ribbons or nests

NP

NP

PCK+, NSE+, CHR+, SYN+

Kurzer et al, 2005 [6]

Right/Cyst filled with tan-brown friable material and three irregular tan-brown stones

Mid-lower pole/1

Transitional, colonic, squamous, and non-specific cuboidal epithelium, mature adipose, focal osseous metaplasia

Nests and cords

Small cells with peripheral palisading

NP

CHR+

Current case

Right/Cyst with irregular pale tan wall and focal calcifications

Middle pole/2

Urothelial-type and colonic epithelium, focal mature bone

Trabecular and anastomosing ribbon-like nests

Monotonous small round cells with peripheral palisading, and "salt-and-pepper" chromatin pattern

0/10 HPF

SYN+, CD 56+, PCK+, THY+, CK 7-, CK 20-, CAR-, PR-, ER-, S-100-, Melan-A-, INS-, TTF-1-, CHR-,

  1. *NP, not provided; HPF; high power field; SYN, synaptophysin; PCK, pancytokeratin; THY, thyroxine; CK, cytokeratin; CAR, calretinin; PR, progesterone receptor; ER, estrogen receptor; INS, insulin; TTF, thyroid transcription factor; CHR, chromogranin; NSE, neuron specific enolase; SER, serotonin; PSA, prostate specific antigen; GLU, glucagon; SOM, somatostatin; ACTH, adrenocorticotropic hormone; CAL, calcitonin; GAS, gastrin; MOT, motilin; NEU, neurotensin