Primary angiosarcoma of the testis: report of a rare entity and review of the literature

Diagnostic Pathology

Table 2 Pathologic characteristics of primary testicular angiosarcoma

Source, year	Macroscopic findings of angiosarcoma
	Gross	Site	Size, cm	Architectural patterns of angiosarcoma	Cytologic features	Mitotic rate	Immuno-phenotype
Hughes et al, 1991 [1]	*Flesh-colored intervening stroma	Testicular parenchyma	9	* Classic	Typical	NA	FVII⁺, UEL⁺
Masera et al, 1999 [2]	Well-vascularised lesion	Testicular parenchyma	1.7	Classic	Epithelioid	High	FVIII⁺, UEL⁺, CD31⁺, CD34⁺, Pancytokeratin^-, CD68^-, LCA^-, PLAP^-
Steele et al, 2000 [3]	*Vascular solid mass	Testicular parenchyma with invasion of rete testis, epididymis, and spermatic cord	8	*Classic	Epithelioid	NA	FVIII⁺, CD31⁺
Sahoo et al, 2003 [4]	#Vascular solid mass	#Retroperitoneum	10	#Classic, focally solid	Epithelioid and spindled	NA	CD31⁺, CD34⁺, AE1/AE3^-, CAM5.2^-, PLAP^-
Current case	Solid vascular nodule	Testicular parenchyma with invasion of epididymis	3	Classic, focally solid	Typical	8/10 HPF	UEL⁺, CD31⁺, CD34⁺, AE1/AE3^-, Pancytokeratin^-

NA: not available; FVIII, factor VIII-related antigen; UEL, Ulex europaeus lectin, LCA, leucocyte common antigen; PLAP, placental alkaline phosphatase.
*Concurrent presence of multiloculated cystic areas diagnosed as mature teratoma in the same testicular tumor.
#Concurrent presence of multiloculated cystic testicular tumor diagnosed as mature teratoma.

ISSN: 1746-1596