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Are there different vascular pathologies in non-hereditary neuropathies of axonal type?


This study refers to the problem of the etiological heterogenity of primary axonal neuropathies, which appear in a relatively monotonous morphology. Investigations of the vascular parenchyma of peripheral nerve biopsies were carried out to determine possible specific vascular pathomorphological features in context of each patient's medical history.


Sural nerve biopsies of the last 3 years in our institute were studied (n = 76). Cases with primary axonal neuropathic changes were investigated with regard to the vascular pathology of epi- and endoneural vessels. Conventional histology, immunohistochemistry and electron microscopy were performed and a semiquantitative analysis of number, distribution and thickness of vessels and cellular proliferation is given.


In our examination of the nerve parenchymal vessels, four groups with common patterns of vasopathic lesions could be subdivided: 1) primary endoneural microangiopathic type; 2) primary endo- and epineural angiopathic type with involvement of small arteries and heterogenous distribution of axonal atrophy; 3) subtype with fibromuscluar dysplastic-like features; 4) secondary concentric stenosing type of endo- and epineural vessels after inflammatory or demyelinating diseases.


In view of the uniform morphological appearance of the peripheral nervous parenchyma in cases of axonal neuropathy the precise examination of the vasculature can help in elucidating the etiopathogenesis of the underlying disease. To achieve the best clinicopathological correlation full access to all clinical data is an urgent condition.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mueller, K., Nagel, A. & Volk, B. Are there different vascular pathologies in non-hereditary neuropathies of axonal type?. Diagn Pathol 2 (Suppl 1), S19 (2007).

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