Volume 2 Supplement 1

35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR)

Open Access

Are there different vascular pathologies in non-hereditary neuropathies of axonal type?

  • K Mueller1,
  • A Nagel2 and
  • B Volk1
Diagnostic Pathology20072(Suppl 1):S19


Published: 14 March 2007


This study refers to the problem of the etiological heterogenity of primary axonal neuropathies, which appear in a relatively monotonous morphology. Investigations of the vascular parenchyma of peripheral nerve biopsies were carried out to determine possible specific vascular pathomorphological features in context of each patient's medical history.


Sural nerve biopsies of the last 3 years in our institute were studied (n = 76). Cases with primary axonal neuropathic changes were investigated with regard to the vascular pathology of epi- and endoneural vessels. Conventional histology, immunohistochemistry and electron microscopy were performed and a semiquantitative analysis of number, distribution and thickness of vessels and cellular proliferation is given.


In our examination of the nerve parenchymal vessels, four groups with common patterns of vasopathic lesions could be subdivided: 1) primary endoneural microangiopathic type; 2) primary endo- and epineural angiopathic type with involvement of small arteries and heterogenous distribution of axonal atrophy; 3) subtype with fibromuscluar dysplastic-like features; 4) secondary concentric stenosing type of endo- and epineural vessels after inflammatory or demyelinating diseases.


In view of the uniform morphological appearance of the peripheral nervous parenchyma in cases of axonal neuropathy the precise examination of the vasculature can help in elucidating the etiopathogenesis of the underlying disease. To achieve the best clinicopathological correlation full access to all clinical data is an urgent condition.

Authors’ Affiliations

Abt. Neuropathologie, Universität Freiburg
Pathologisches Institut, Städtisches Klinikum Karlsruhe


© Mueller et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.