Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry

Diagnostic Pathology

Table 6 Sensitivity and specificity, confirmed MM cases

Marker	Sensitivity, MM			Specificity, against carcinoma
Positive MM markers	positive IR, number	positive IR, %	literature data, %	negative IR, number %	negative IR, %	literature data, %
Calretinin, nucleus	49/49	100	82¹ 96.4²	5/5	100	85^1;2
EMA, cell membrane	43/49	87.8	84³	3/5	60	56³
Podoplanin, cell membrane	44/46	95.6	86⁴	2/3	66.7	100⁴
Mesothelin, cell membrane	44/48	91.7	100⁵	4/4	100	61⁵
Thrombomodulin, cell membrane	7/7	100	61¹	2/5	40	80¹
HBME-1, cell membrane or cytoplasm	(4+2)/8	75	85¹	(2-1)/5	20	43¹
CK5/6	3/3	100	83¹	3/5	60	85¹
Negative MM markers	negative IR, number	negative IR, %		positive IR, number	positive IR, %
CEA, monoclonal	49/49	100	81¹	1/5	20	97¹
Ber-Ep4	40/49	81.6	80¹	3/5	60	90¹
CD15	7/7	100	84.9⁶	1/5	20	81⁶
Sialosyl-TN	6/7	85.7	76.5⁶	1/5	20	81⁶
TTF-1	3/3	100	72¹	5/5	100	100¹

Specificity, own results: against AC and pulmonary pleomorphic carcinoma.
Comparison to some selected data from literature.
¹ King et al. 2006, meta-analysis of literature data, MM with epithelioid areas against pulmonary AC [27].
² Takeshima et al. 2009: sensitivity epithelial/mixed MM 96.4%/90% [1]. Yaziji et al. 2006: sensitivity 95%, specificity against AC 87%, both with 10% positive cutoff [28].
^{1, 2} Calretinin IR not specified.
³ Wick et al. 1990, related to epithelial MM and pulmonary AC [29].
⁴ Ordóñez 2005, related to epithelial MM and AC [21].
⁵ Ordóñez 2003a, related to epithelial MM and pulmonary AC [30].
⁶ Brockstedt et al. 2000, related to epithelial/mixed MM and AC [31].

ISSN: 1746-1596