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Table 3 Whole tissue section intra-reader agreement and agreement between the second whole tissue section and TMA

From: Tissue microarrays: one size does not fit all

  B7-H1 B7-H3 Survivin Ki-67 CAIX* IMP3
  Kappa CCC CCC CCC CCC CCC
Whole section 0.78 0.97 0.71 0.90 0.94 0.96
Cores       
1 0.21 (0.00 - 0.65) 0.80 (0.73 - 0.87) 0.35 (0.06 - 0.55) 0.63 (0.44 - 0.82) 0.85 (0.73 - 0.94) 0.73 (0.02 - 0.87)
2 0.21 (0.00 - 0.65) 0.81 (0.74 - 0.87) 0.40 (0.12 - 0.57) 0.72 (0.49 - 0.84) 0.82 (0.73 - 0.92) 0.79 (0.20 - 0.85)
3 0.38 (0.00 - 0.65) 0.83 (0.76 - 0.86) 0.43 (0.24 - 0.62) 0.76 (0.62 - 0.86) 0.80 (0.72 - 0.89) 0.81 (0.49 - 0.85)
4 0.38 (0.00 - 0.65) 0.83 (0.77 - 0.85) 0.44 (0.33 - 0.58) 0.79 (0.64 - 0.85) 0.78 (0.71 - 0.87) 0.82 (0.61 - 0.85)
5 0.52 (0.00 - 0.65) 0.83 (0.80 - 0.85) 0.45 (0.36 - 0.57) 0.81 (0.71 - 0.86) 0.77 (0.72 - 0.84) 0.82 (0.77 - 0.85)
6 0.52 (0.00 - 0.65) 0.84 (0.81 - 0.84) 0.45 (0.37 - 0.57) 0.81 (0.71 - 0.85) 0.76 (0.71 - 0.82) 0.82 (0.77 - 0.85)
7 0.65 (0.00 - 0.65) 0.84 (0.81 - 0.84) 0.46 (0.40 - 0.52) 0.82 (0.73 - 0.85) 0.75 (0.72 - 0.82) 0.82 (0.77 - 0.85)
8 0.65 (0.38 - 0.65) 0.84 (0.83 - 0.84) 0.46 (0.41 - 0.51) 0.82 (0.76 - 0.84) 0.74 (0.72 - 0.81) 0.82 (0.79 - 0.85)
9 0.65 (0.52 - 0.65) 0.84 (0.83 - 0.84) 0.46 (0.43 - 0.48) 0.82 (0.79 - 0.84) 0.73 (0.72 - 0.79) 0.82 (0.80 - 0.84)
10 0.65 (0.65 - 0.65) 0.84 (0.84 - 0.84) 0.46 (0.46 - 0.46) 0.82 (0.82 - 0.82) 0.73 (0.73 - 0.73) 0.82 (0.82 - 0.82)
  1. *CAIX was analyzed using the minimum value across cores. All other biomarkers were analyzed using the maximum value across cores.
  2. The kappa statistic is reported for B7-H1, whereas the concordance correlation coefficient (CCC) is reported for B7-H3, survivin, Ki-67, CAIX, and IMP3; the median (minimum, maximum) statistic from the 500 bootstrap samples is provided.