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Table 2 Results of immunohistochemical markers response in glial cells

From: The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events

  Acute (A) (≤8 hs) Median Expression Non-acute (NA) (≥8 hs ≤48 hs) Median Expression Controls (C) Median Expression Significant Significance Level Levels
GFAP +++ +++ +++ A vs C ns
     NA vs C ns
     A vs NA ns
TNF-α - + - A vs C ***
     NA vs C ns
     A vs NA ***
IL-1β - + - A vs C ***
     NA vs C ns
     A vs NA ***
IL-6 - ++ - A vs C ***
     NA vs C ns
     A vs NA ***
MAC387 ++ + - A vs C ***
     NA vs C ***
     A vs NA **
HSP 27 - - - A vs C ns
     NA vs C ns
     A vs NA ns
HSP 70 + ++ - A vs C ***
     NA vs C ***
     A vs NA ***
HSP 90 + ++ - A vs C ***
     NA vs C ***
     A vs NA ***
COX2   ++ - A vs C ***
     NA vs C ns
     A vs NA ***
ORP-150 - ++ - A vs C ***
     NA vs C ns
     A vs NA ***
β-APP + ++ ++ A vs C ***
     NA vs C ***
     A vs NA ns
TrypH - - - A vs C ns
     NA vs C ns
     A vs NA ns
GAP-43 - + - A vs C ***
     NA vs C ns
     A vs NA ***
Apoptosis (TUNEL) + ++ - A vs C ***
     NA vs C ***
     A vs NA ***
  1. The reactions were graded as follows: 1. (0): not expressed, 2. (+): isolated and disseminated expression, 3. (++): expression in groups or widespread foci, 4. (+++): widespread expression.
  2. NS = p > 0.05, * = p < 0.05, ** = p < 0.01, *** = p < 0.001