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Table 2 Correlation between FISH EGFR and immunohistochemicals markers (mEGFR, nEGFR and Cyclin D1)

From: Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification

   EGFR FISH  
Parameters Total ≤ 2,0 - 2,49 2,5 - 2,93 ≥ 2,94 p - value
mEGFR      0.001
   neg./week 49 49 0 0  
   moderate 64 53 8 3  
   strong 22 15 2 5  
nEGFR      0.818
   neg./week 9 9 0 0  
   moderate 49 42 2 5  
   strong 77 66 8 3  
Cyclin D1      0.876
   neg./week 8 7 1 0  
   moderate 51 45 1 5  
   strong 76 65 8 3  
Total 135 117    
  1. CRC, colorectal carcinoma
  2. mEGFR, membrane EGFR
  3. nEGFR, nuclear EGFR
  4. test - Spearman rank correlation coefficient