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Figure 2 | Diagnostic Pathology

Figure 2

From: Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma

Figure 2

Representative photographs of CD44 extracellular domain, Zo-1, and occludin expression. CD44 extracellular domain is not expressed at the cell membrane of the invasive part of ulcerative colitis (UC)-associated well differentiated carcinoma (A) and a poorly differentiated carcinoma (B). On the other hand, in a case of sporadic well differentiated (C) and a case of sporadic poorly differentiated adenocarcinoma (D), membranous expression of CD44 extracellular domain is observed. Linear expression of Zo-1 (E) and occludin (F) is seen at the luminal surface in a case of UC-associated well differentiated carcinoma. However, in a UC-associated poorly differentiated case, dot-like expression of both Zo-1 (G) and occludin (H) is observed on the cell surface.

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Diagnostic Pathology

ISSN: 1746-1596

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