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Table 5 Promoter methylation in NSCLC-multivariable models assessing smoking history, histologic type, lymph node metastasis, and pleural indentation (OR and 95% CI)

From: Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC)

Genes Smoking history SCC vs. ADC Lymph node metastasis Pleural indentation
CALCA 1.07 (0.40-2.88) 2.66 (0.85-8.32) 1.43 (0.46-4.41) 2.19 (0.61-7.79)
CDH1 0.98 (0.37-2.58) 6.77 (1.71-26.8)* 0.78 (0.29-2.13) 5.27 (1.27-21.9)*
DAPK1 0.83 (0.19-3.73) 10.7 (2.16-52.6)* 3.07 (0.32-29.4) 6.98 (1.06-45.8)*
IRX2 0.69 (0.26-1.83) 6.38 (1.77-23.0)* 0.85 (0.31-2.33) 3.89 (1.01-15.0)*
TIMP3 0.78 (0.30-2.02) 3.37 (1.03-11.0)* 1.75 (0.65-4.75) 2.66 (0.77-9.16)
PAX6 0.67 (0.21-2.08) 1.82 (0.50-6.57) 0.77 (0.25-2.38) 2.66 (0.58-12.3)
  1. † OR: odds ratio with 95% confidence interval, adjusted for multiple comparisions.
  2. * Significant at P < 0.05.