Skip to main content

Table 1 Comparison between Carney triad GIST (case 1), pediatric (case 2) and young adult GIST (case 3)

From: Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: A comparative clinical and histomorphological study of three cases including a new case of Carney triad

  CT-GIST (case 1) Pediatric GIST (case 2) Young adult GIST (case 3)
Age at diagnosis (years) 15 13 23
Gender female female female
Tumor localisation stomach, greater
curvature, antrum
stomach, lesser
curvature, antrum
stomach, corpus
Growth pattern multinodular multinodular multinodular
Metastases liver
(lymphangioinvasion)
liver
lymph nodes
liver
lymph nodes
Histomorphology biphasic (spindled and
epithelioid),
hypercellular,
plasmacytoid aspect
biphasic (spindled and
epithelioid),
hypercellular,
plasmacytoid aspect
liver metastasis:
hypercellular,
plasmacytoid aspect
lymph node
metastasis: closely
packed hypercellular
tumor nodules with
lymphangioinvasion
Immunohisto-
chemistry
C-KIT/CD34 +
(predominantly
membranous)
C-KIT/CD34 +
(predominantly
membranous)
C-KIT/CD34 +
(predominantly
membranous)
Mutational status WT for common C-KIT
(exon 9,11,13,17) and
PDGFRA (exon
12,14,18) mutations
PDGFRA Exon 10
polymorphism (c. 1432
T > C; p. S478P, no
alteration on protein
level)
WT for common C-KIT
(exon 9,11,13,17) and
PDGFRA (exon
12,14,18) mutations
WT for common C-KIT
(exon 9,11,13,17) and
PDGFRA (exon
12,14,18) mutations
Associated diseases paraaortal
paraganglioma
? ?
  1. CT = Carney triad, GIST = gastrointestinal stromal tumor, WT = wild type, ? = not to date