From: Decreased D2-40 and increased p16INK4A immunoreactivities correlate with higher grade of cervical intraepithelial neoplasia
p16INK4Aexpression (%)
Lesion type
n
negative
focal
diffuse
Positivity
Normal cervix
21
21 (100%)
0 (0)
0
CIN 1
32
2 (6.2%)
18 (56.3%)
12 (37.5%)
93.8%
CIN 2
37
13 (35.1%)
24 (64.9%)
100%
CIN 3
35
7 (20.0%)
28 (80.0%)