Table 1 Comparsion of the clinicopathologic features of malignant renal solitary fibrous tumor
From: De novo malignant solitary fibrous tumor of the kidney
| Â | Fine et al. | Margo et al. | Present case |
|---|---|---|---|
Age (yr) | 76 | 34 | 50 |
Gender | Female | Female | Female |
Location | Left kidney | Left kidney | Right kidney |
Size | 12 × 10 × 7.5 cm | 9 cm, with a distinct 3-cm nodule | 9 × 9 × 6 cm |
Tumor borders | Infiltrative with invasion beyond the renal capsule | Circumscribed | Circumscribed, unencapsulated |
Necrosis | Focal | Absent | Marked |
Hemorrhage | NA | Absent | Present |
Histology | 10% benign SFT 90% dedifferentiation | 70% benign SFT 30% dedifferentiation | De novo malignant SFT |
Mitoses | Frequent | 2-6/10 HPF | 8/10 HPF |
Atypia | Marked in areas of dedifferentiation | Marked in areas of dedifferentiation | Mild to moderate |
Ki-67 proliferative index | NA | 1-4% | 20% |
CD34 | Loss of expression in areas of dedifferentiation | Positive | Positive |
Follow-up | Multiple lung nodules 4 month after nephrectomy | 15 months, NED | 30 months, NED |