Table 1 Patient and tumour characteristics
Intrinsic subtype | ||||||
|---|---|---|---|---|---|---|
Luminal A | Luminal B | Luminal B HER2+ | HER2+ | Triple-negative | p | |
Age group | n.s | |||||
Age < 55 year (n = 52) | 17 (40) | 14 (52) | 8 (53) | 1 (17) | 12 (67) | |
Age > 55 year (n = 57) | 26 (60) | 13 (48) | 7 (47) | 5 (83) | 6 (33) | |
Histological grade | < 0.0001 | |||||
1 | 16 (37) | 2 (8) | 1 (7) | 0 (0) | 0 (0) | |
2 | 26 (61) | 6 (22) | 6 (40) | 3 (50) | 3 (17) | |
3 | 1 (2) | 19 (70) | 8 (53) | 3 (50) | 15 (83) | |
T | n.s. | |||||
1 | 28 (65) | 13 (48) | 8 (53) | 3 (50) | 6 (33) | |
2 | 15 (35) | 14 (52) | 7 (47) | 3 (50) | 12 (67) | |
N | n.s. | |||||
0 | 27 (63) | 13 (48) | 8 (53) | 4 (67) | 14 (78) | |
1 | 16 (37) | 14 (52) | 7 (47) | 2 (33) | 4 (22) | |
% positive cells by immunohistochemistry measured by digital image analysis (mean ± SD)* | ||||||
ER | 80 ± 13 | 62 ± 33 | 52 ± 26 | 2 ± 1 | 4 ± 7 | < 0.0001 |
PR | 53 ± 31 | 38 ± 36 | 19 ± 29 | 2 ± 2 | 3 ± 4 | < 0.0001 |
AR | 47 ± 20 | 32 ± 23 | 28 ± 21 | 33 ± 15 | 10 ± 15 | < 0.0001 |
BCL2 | 56 ± 11 | 46 ± 24 | 33 ± 27 | 7 ± 6 | 18 ± 15 | < 0.0001 |
HER2 | 7 ± 11 | 7 ± 12 | 37 ± 25 | 64 ± 19 | 1 ± 3 | < 0.0001 |
Ki67 | 14 ± 7 | 40 ± 17 | 22 ± 12 | 31 ± 15 | 53 ± 16 | < 0.0001 |
p53 | 13 ± 16 | 34 ± 32 | 19 ± 18 | 17 ± 26 | 44 ± 35 | n.s. |
p16 | 14 ± 8 | 14 ± 12 | 14 ± 7 | 10 ± 4 | 40 ± 21 | < 0.0001 |
HIF-1α | 9 ± 6 | 12 ± 10 | 12 ± 10 | 18 ± 13 | 18 ± 10 | < 0.005 |
SATB1 | 12 ± 7 | 14 ± 10 | 13 ± 10 | 10 ± 4 | 19 ± 18 | n.s. |