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Table 5 Staining Scores in SMPC, AMPC and nMPC lesions

From: Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma

Classification/Antibody

SMPC

AMPC

nMPC

Cellular adhesion molecules

   

   E-cadherin

215.3*

143.9

187.1

   CD44

60.8‡

205.9¶

141.3

   Laminin5γ2

69.4

36.9

60.3

Growth factor

  

   VEGF-C

294.4

296.4

282.1

Apoptosis-associated proteins

  

   bcl2

13.2

11.1

21.8

   p53§

36.4

26.1

45.0

   cleaved caspase-3§

0.3

0.2

0.4

Mucin-related proteins

   

   MUC1

169.7

182.5

202.1

   MUC6

0.0

0.0

0.0

Hypoxia induced protein

   

   HIF-1α

1.8

2.4

2.9

Others

   

   TTF-1

267.9

289.3

248.6

   SP-A

45.2‡

82.6

123.2

   Vimentin

112.1

117.9

72.1

   Ki-67§

22.6

16.9

16.2

   LYVE1

98.9

107.2

101.9

   c-Met

217.2

253.8

211.4

   Phospho-c-Met

34.2‡

50.0

88.0

  1. SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; nMPC, non-micropapillary component; VEGF-C, vascular endothelial growth factor-C; HIF-1α, hypoxia induced factor 1-α; TTF-1, thyroid transcription factor-1; SP-A, surfactant apoprotein A; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1.
  2. § Positivity rate of positive tumor cells in 300 tumor cells (percentage).
  3. * The difference in staining scores between SMPC and AMPC is statistically significant (P = 0.020).
  4. ‡ The differences in staining scores between SMPC and nMPC are statistically significant for CD44 (P = 0.011), and SP-A (P = 0.024) and phospho-c-Met (P = 0.011) expression.
  5. ¶ The difference in staining scores between AMPC and nMPC is statistically significant (P = 0.015).
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Diagnostic Pathology

ISSN: 1746-1596

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