Test method | Cytological analysis | FISH test | |||
---|---|---|---|---|---|
Cut-off value†| ASCUS+ | TERC+ | C-MYC+ | TERC + and C-MYC+ | TERC + or C-MYC+ |
Sensitivity, % (95%CI) | 84.0 (73.8-94.2) | 90.0(81.7-98.3) | 80.0 (68.9-91.2) | 78.0 (66.5-89.5) | 92.0 (84.5-99.5) |
Specificity, % (95%CI) | 64.3(57.5-71.0) | 89.6(85.3-93.9) | 77.7 (71.8-83.6) | 95.3 (92.3-98.3) | 72.0 (65.7-78.3) |
PPV, % (95%CI) | 37.8(28.8-46.9) | 69.2(58.0-80.5) | 48.2 (37.5-59.0) | 81.3 (70.3-92.3) | 46.0 (36.2-55.8) |
NPV, % (95%CI) | 93.9(89.9-98.0) | 97.2(94.8-99.6) | 93.8 (90.1-97.5) | 94.4 (91.2-97.6) | 97.2 (94.5-99.9) |
Accuracy, % (95%CI) | 68.3(62.5-74.2) | 89.7(85.9-93.5) | 78.2 (73.0-83.4) | 91.8 (88.4-95.3) | 76.1 (70.7-81.5) |
Youden's index, % (95%CI) | 48.3(31.3-65.2) | 79.6(67.0-92.3) | 57.7 (40.7-74.8) | 73.3 (58.8-87.5) | 64.0 (50.2-77.8) |