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Table 5 Comparison of cytological analysis and the FISH test for CIN2+ diagnosis

From: Genomic amplification patterns of human telomerase RNA gene and C-MYC in liquid-based cytological specimens used for the detection of high-grade cervical intraepithelial neoplasia

Test method Cytological analysis FISH test
Cut-off value† ASCUS+ TERC+ C-MYC+ TERC + and C-MYC+ TERC + or C-MYC+
Sensitivity, % (95%CI) 84.0 (73.8-94.2) 90.0(81.7-98.3) 80.0 (68.9-91.2) 78.0 (66.5-89.5) 92.0 (84.5-99.5)
Specificity, % (95%CI) 64.3(57.5-71.0) 89.6(85.3-93.9) 77.7 (71.8-83.6) 95.3 (92.3-98.3) 72.0 (65.7-78.3)
PPV, % (95%CI) 37.8(28.8-46.9) 69.2(58.0-80.5) 48.2 (37.5-59.0) 81.3 (70.3-92.3) 46.0 (36.2-55.8)
NPV, % (95%CI) 93.9(89.9-98.0) 97.2(94.8-99.6) 93.8 (90.1-97.5) 94.4 (91.2-97.6) 97.2 (94.5-99.9)
Accuracy, % (95%CI) 68.3(62.5-74.2) 89.7(85.9-93.5) 78.2 (73.0-83.4) 91.8 (88.4-95.3) 76.1 (70.7-81.5)
Youden's index, % (95%CI) 48.3(31.3-65.2) 79.6(67.0-92.3) 57.7 (40.7-74.8) 73.3 (58.8-87.5) 64.0 (50.2-77.8)
  1. † Cut-off value: ASCUS + determined as ASCUS or higher. TERC + determined as ≥ 5% aberrant TERC cells among all of the cells observed. C-MYC + determined as ≥ 3% aberrant C-MYC cells among all of the cells observed