Single IHC | ||||
---|---|---|---|---|
 | Gene-protein IHC | Positive | Negative | Total |
Reader A | Positive | 50 | 2 | 52 |
 | Negative | 0 | 131 | 131 |
 | Total | 50 | 133 | 183 |
 | PPA: n/N (%) (95% CI) | 50/50 (100.0) (92.9–100.0) |  |  |
 | NPA: n/N (%) (95% CI) | 131/133 (98.5) (94.7–99.6) |  |  |
 | OPA: n/N (%) (95% CI) | 181/183 (98.9) (96.1–99.7) |  |  |
 | Kappa coefficient (95% CI) | 0.97 (0.94–1.00) |  |  |
Reader B | Positive | 47 | 3 | 50 |
 | Negative | 1 | 132 | 133 |
 | Total | 48 | 135 | 183 |
 | PPA: n/N (%) (95% CI) | 47/48 (97.9) (89.1–99.6) |  |  |
 | NPA: n/N (%) (95% CI) | 132/135 (97.8) (93.7–99.2) |  |  |
 | OPA: n/N (%) (95% CI) | 179/183 (97.8) (94.5–99.1) |  |  |
 | Kappa coefficient (95% CI) | 0.94 (0.89–1.00) |  |  |
Reader C | Positive | 54 | 1 | 55 |
 | Negative | 0 | 128 | 128 |
 | Total | 54 | 129 | 183 |
 | PPA: n/N (%) (95% CI) | 54/54 (100.0) (93.4–100.0) |  |  |
 | NPA: n/N (%) (95% CI) | 128/129 (99.2) (95.7–99.9) |  |  |
 | OPA: n/N (%) (95% CI) | 182/183 (99.5) (97.0–99.9) |  |  |
 | Kappa coefficient (95% CI) | 0.99 (0.96–1.00) |  |  |