Table 6 Gene-protein BISH (comparator) vs. single BISH (reference) agreement analyses
Single BISH | ||||
|---|---|---|---|---|
| Â | Gene-protein BISH | Amplified | Non-amplified | Total |
Reader A | Amplified | 43 | 2 | 45 |
| Â | Non-amplified | 2 | 118 | 120 |
| Â | Total | 45 | 120 | 165 |
|  | PPA: n/N (%) (95% CI) | 43/45 (95.6) (85.2–98.8) |  |  |
|  | NPA: n/N (%) (95% CI) | 118/120 (98.3) (94.1–99.5) |  |  |
|  | OPA: n/N (%) (95% CI) | 161/165 (97.6) (93.9–99.1) |  |  |
|  | Kappa coefficient (95% CI) | 0.94 (0.88–1.00) |  |  |
Reader B | Amplified | 47 | 1 | 48 |
| Â | Non-amplified | 3 | 121 | 124 |
| Â | Total | 50 | 122 | 172 |
|  | PPA: n/N (%) (95% CI) | 47/50 (94.0) (83.8–97.9) |  |  |
|  | NPA: n/N (%) (95% CI) | 121/122 (99.2) (95.5–99.9) |  |  |
|  | OPA: n/N (%) (95% CI) | 168/172 (97.7) (94.2–99.1) |  |  |
|  | Kappa coefficient (95% CI) | 0.94 (0.89–1.00) |  |  |
Reader C | Amplified | 41 | 5 | 46 |
| Â | Non-amplified | 2 | 125 | 127 |
| Â | Total | 43 | 130 | 173 |
|  | PPA: n/N (%) (95% CI) | 41/43 (95.3) (84.5–98.7) |  |  |
|  | NPA: n/N (%) (95% CI) | 125/130 (96.2) (91.3–98.3) |  |  |
|  | OPA: n/N (%) (95% CI) | 166/173 (96.0) (91.9–98.0) |  |  |
|  | Kappa coefficient (95% CI) | 0.89 (0.82–0.97) |  |  |