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Table 2 EZH2 staining

From: Enhancer of zeste homologue 2 (EZH2) is a reliable immunohistochemical marker to differentiate malignant and benign hepatic tumors

EZH2 expression Negative (score0) Weak (score1) Moderate (score2) Strong (score3) Sensitivity/Specificity
Hepatocellular carcinoma (n = 44)      0.90/0.33
 Grade I. 2 6 4 0  
 Grade II. 1 12 7 2  
 Grade III 1 4 2 2  
 Grade IV. 0 1 0 0  
CC (n = 23)      0.96/0.18
 Grade I. 0 2 2 1  
 Grade II. 1 2 9 2  
 Grade III 0 1 3 0  
Hepatoblastoma (n = 31) 2 6 9 14 0.94/0.24
Hepatocellular adenoma (n = 24) 24 0 0 0 0/0
Biliary cystadenoma (n = 3) 3 0 0 0 0/0
Metastases      NC*
 Colon (n = 8) 0 0 5 3  
 Breast (n = 2) 0 0 2 0  
 Lung (n = 2) 0 0 0 2  
 Neuroendocrine (n = 3) 3 0 0 0  
 Urothel (n = 1)     1  
 Pancreas (n = 1)    1   
Childhood tumors      NC*
 Rhabdomyosarcoma (n = 4) 0 1 2 1  
 Neuroblastoma (n = 5) 0 0 3 2  
 Wilms’ tumor (n = 5) 0 1 1 3  
 Rhabdoid tumor (n = 2) 0 0 1 1  
Non tumorous lesions      
High grade dysplastic nodule (n = 15) 15 0 0 0  
Biliary hamartoma (n = 3) 3 0 0 0  
Caroli’s disease (n = 3) 3 0 0 0  
  1. *NC not counted due to low case number.