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Table 1 Associations of MSI screening status and beta-catenin expression with clinicopathological characteristics

From: Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer

  MSI screening status Beta-catenin score  
n (%) MSS MSI P-value 0-1 2-3 4-5 P-value
  438(85.0) 77(15.0)   159(30.2) 170(32.3) 198(37.6)  
Age        
 <=75 308(70.3) 41(53.2) 0.003* 101(63.5) 123(72.4) 133(67.2) 0.561
 >75 130(29.7) 36(46.8)   58(36.5) 47(27.6) 65(32.8)  
Sex        
 Female 222(50.7) 50(64.9) 0.021* 87(54.7) 90(52.9) 100(50.5) 0.425
 Male 216(49.3) 27(35.1)   72(45.3) 80(47.1) 98(49.5)  
Tumour location        
 Proximal 107(24.5) 62(80.5) <0.001** 84(53.2) 50(29.4) 37(18.8) <0.001**
 Transverse 12(2.8) 8(10.4)   11(7.0) 7(4.1) 5(2.5)  
 Descending 26(6.0) 1(1.3)   6(3.8) 11(6.5) 9(4.6)  
 Sigmoid 105(24.1) 3(3.9)   19(12.0) 31(18.2) 60(30.5)  
 Rectum 186(42.7) 3(3.9)   38(24.1) 71(41.8) 86(43.7)  
 Unknown 2 0   1 0 1  
T stage        
 1 45(10.8) 3(3.9) 0.116 12(8.0) 11(6.9) 23(11.9) 0.039*
 2 53(12.7) 7(9.2)   14(9.3) 21(13.1) 27(14.0)  
 3 257(61.5) 54(71.1)   99(66.0) 100(62.5) 119(61.7)  
 4 63(15.1) 12(15.8)   25(16.7) 28(17.5) 24(12.4)  
 missing 20 1   9 10 5  
N stage        
 0 222(56.5) 54(72.0) 0.017* 84(57.5) 86(55.8) 109(60.9) 0.249
 1 101(25.7) 12(16.0)   28(19.2) 44(28.6) 44(24.6)  
 2 70(17.8) 9(12.0)   34(23.3) 24(15.6) 26(14.5)  
 missing 45 2   13 16 19  
M stage        
 0 352(81.7) 72(93.5) 0.010* 123(78.8) 140(83.3) 166(85.1) 0.131
 1 79(18.3) 5(6.5)   33(21.2) 28(16.7) 29(14.9)  
 missing 7 0   3 2 3  
Differentiation grade        
 High 28(6.5) 6(8.0) 0.003** 16(10.3) 8(4.8) 10(5.1) 0.016*
 Intermediate 321(74.5) 40(53.3)   94(60.3) 115(69.3) 159(81.5)  
 Low 82(19.0) 29(38.7)   46(29.5) 43(25.9) 26(13.3)  
 missing 7 2   3 4 4  
Vascular invasion        
 No 121(47.8) 26(57.8) 0.220 48(50.5) 33(36.3) 68(58.1) 0.177
 Yes 132(52.2) 19(42.2)   47(49.5) 58(63.7) 49(41.9)  
 missing 185 32   64 79 81  
  1. Columnar percentage in parentheses. χ2-test of association was used for 2x2 tables and χ2-test for linear trend for tables with more than two rows and/or columns. The categories marked as missing were not included in the analysis. *Significant at the 0.05 level. **Significant at the 0.01 level. N1 = 1-3 positive nodes, N2= > 4 positive nodes. MSS = Microsatellite stable, MSI = Microsatellite unstable. Proximal colon = appendix, cecum, ascending colon, hepatic flexure; descending colon = splenic flexure and descending colon.