Table 2 Associations of MSI screening status and beta-catenin expression with expression of p21, p27 and p53
MSI screening status | Beta-catenin score | ||||||
|---|---|---|---|---|---|---|---|
n (%) | MSS | MSI | P-value | 0-1 | 2-3 | 4-5 | P-value |
438(85.0) | 77(15.0) | 159(30.2) | 170(32.3) | 198(37.6) | |||
P53 status | |||||||
Negative | 196(40.0) | 62(80.5) | <0.001** | 101(65.2) | 92(55.1) | 76(38.6) | <0.001** |
Positive | 230(54.0) | 15(19.5) | 54(34.8) | 75(44.9) | 121(61.4) | ||
missing | 12 | 0 | 4 | 3 | 1 | ||
Cyclin D1 fraction | |||||||
0-1% | 94(22.1) | 2(2.6) | <0.001** | 36(23.4) | 36(21.7) | 31(15.8) | 0.001** |
2-25% | 159(37.4) | 26(34.2) | 63(40.9) | 65(39.2) | 63(32.1) | ||
26-50% | 65(15.3) | 16(21.1) | 20(13.0) | 29(17.5) | 33(16.8) | ||
51-75% | 87(20.5) | 25(32.9) | 27(17.5) | 32(19.3) | 53(27.0) | ||
>75% | 20(4.7) | 7(9.2) | 8(5.2) | 4(2.4) | 16(8.2) | ||
missing | 13 | 1 | 5 | 4 | 2 | ||
Cyclin D1 intensity | |||||||
Negative | 94(22.1) | 2(2.6) | <0.001** | 36(23.4) | 36(21.7) | 31(15.8) | 0.085 |
Weak | 154(36.2) | 20(26.3) | 51(33.1) | 59(35.5) | 68(34.7) | ||
Moderate | 129(30.4) | 41(53.9) | 49(31.8) | 55(33.1) | 68(34.7) | ||
Strong | 48(11.3) | 13(17.1) | 18(11.7) | 16(9.6) | 29(14.8) | ||
missing | 13 | 1 | 5 | 4 | 2 | ||
P27 fraction | |||||||
0-1% | 54(12.7) | 24(31.2) | 0.003** | 43(27.9) | 33(19.8) | 8(4.1) | <0.001** |
2-25% | 96(22.6) | 14(18.2) | 36(23.4) | 43(25.7) | 35(17.9) | ||
26-50% | 90(21.2) | 16(20.8) | 32(20.8) | 40(24.0) | 36(18.4) | ||
51-75% | 134(31.5) | 15(19.5) | 31(20.1) | 36(21.6) | 83(42.3) | ||
>75% | 51(12.0) | 8(10.4) | 12(7.8) | 15(9.0) | 34(17.3) | ||
missing | 13 | 1 | 5 | 3 | 2 | ||
P27 intensity | |||||||
Negative | 54(12.7) | 24(31.2) | <0.001** | 43/27.9) | 33(19.8) | 8(4.1) | <0.001** |
Weak | 96(22.6) | 22(28.6) | 46(29.9) | 39(23.4) | 37(18.9) | ||
Moderate | 142(33.4) | 18(23.4) | 50(32.5) | 51(30.5) | 62(31.6) | ||
Strong | 133(31.3) | 13(16.9) | 15(9.7) | 44(26.3) | 89(45.4) | ||
missing | 13 | 1 | 5 | 3 | 2 | ||
P21 fraction | |||||||
0-1% | 69(16.3) | 3(3.9) | 0.002** | 25(16.2) | 27(16.2) | 25(12.9) | 0.835 |
2-25% | 233(55.1) | 41(53.2) | 81(52.6) | 90(53.9) | 112857.7) | ||
26-50% | 60(14.2) | 18(23.4) | 24(15.6) | 28(16.8) | 26(13.4) | ||
51-75% | 53(12.5) | 13(16.9) | 21(13.6) | 16(9.6) | 30(15.5) | ||
>75% | 8(1.9) | 2(2.6) | 3(1.9) | 6(3.6) | 1(0.5= | ||
missing | 15 | 1 | 5 | 3 | 4 | ||
P21 intensity | |||||||
Negative | 69(16.3) | 3(3.9) | <0.001** | 25(16.2) | 27(16.2) | 25(12.9) | 0.567 |
Weak | 174(41.1) | 24(31.2) | 60(39.0) | 63(37.7) | 81(41.8) | ||
Moderate | 122(28.8) | 36(46.8) | 51(33.1) | 52(31.1) | 60(30.9) | ||
Strong | 58(13.7) | 14(18.2) | 18(11.7) | 25(15.0) | 28(14.4) | ||
missing | 15 | 1 | 5 | 3 | 4 | ||
MSI screening status | |||||||
MSS | - | - | 109(72.7) | 136(83.4) | 184(95.8) | <0.001** | |
MSI | - | - | 41(27.3) | 27(16.6) | 8(4.2) | ||
missing | 9 | 7 | 6 | ||||