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Table 3 Association between the EDNRB methylation in CRC serum and clinicopathologicalfeatures

From: Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer

    EDNRB Methylation   
Characteristics   n M U χ2 p value
Gender Male 28 27 1 0.404 0.525
  Female 14 12 2   
Age(year) ≤60 16 16 0 0.629 0.428
  >60 26 23 3   
Stage 1/2 21 18 3 1.436 0.231
  3/4 21 21 0   
Lymph metastasis Yes 21 21 0 1.436 0.231
  No 21 18 3   
Distant metastasis Yes 8 8 0 0.012 0.913
  No 34 31 3   
CEA ≥5.0 ng/ml 15 14 1 <0.001 1
  <5.0 ng/ml 27 25 2   
CA19-9 ≥37U/ml 9 8 1 <0.001 1
  <37U/ml 33 31 2   
Tumor location Colon 26 24 2 <0.001 1
  Rectum 16 15 1   
Differentiation Poor 10 10 0 0.091 0.763
  Moderate 32 29 3   
  Well 0 0 0   
Tumor size <5 cm 28 25 3 0.404 0.525
  ≥5 cm 14 14 0   
Histological classification Adenocarcinoma 40 37 3 <0.001 1
  Mucinous adenocarcinoma 2 2 0   
  Undifferentiated carcinoma 0 0 0