Table 3 Association between the EDNRB methylation in CRC serum and clinicopathologicalfeatures

Gender

Male

28

27

1

0.404

0.525

Female

14

12

2

Age(year)

≤60

16

16

0

0.629

0.428

>60

26

23

3

Stage

1/2

21

18

3

1.436

0.231

3/4

21

21

0

Lymph metastasis

Yes

21

21

0

1.436

0.231

No

21

18

3

Distant metastasis

Yes

8

8

0

0.012

0.913

No

34

31

3

CEA

≥5.0 ng/ml

15

14

1

<0.001

1

<5.0 ng/ml

27

25

2

CA19-9

≥37U/ml

9

8

1

<0.001

1

<37U/ml

33

31

2

Tumor location

Colon

26

24

2

<0.001

1

Rectum

16

15

1

Differentiation

Poor

10

10

0

0.091

0.763

Moderate

32

29

3

Well

0

0

0

Tumor size

<5 cm

28

25

3

0.404

0.525

≥5 cm

14

14

0

Histological classification

Adenocarcinoma

40

37

3

<0.001

1

Mucinous adenocarcinoma

2

2

0

Undifferentiated carcinoma

0

0

0