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Basic histological features
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Circumscribed lobules made up of basaloid cells with peripheral palisading, no epidermal connection, no retraction space
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Large basaloid epithelial lobules, no epidermal connection, no retraction cleft
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Mutiple lobules and nests of basaloid cells, confined to superficila dermis, no retraction cleft
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Irregular lobues made up of basaloid cells with prominent peripheral palisading, with epidermis attachment and retracion space
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Irregular lobues, with epidermis and follicles attachment
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Specific characteristics
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Centrolobular cell balls, papillary mesenchymal bodies(++), follicular cyst(+/−),
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Papillary mesenchymal bodies(++), follicular cyst(+/−)
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Papillary mesenchymal bodies(+), horn cyst(++)
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Mitotic and apoptotic bodies(+), follicular cyst(+/−), papillary mesenchymal bodies(−)
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Thickened, eosinophilic basement membrane surrounding tumor lobules
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Immunohistochemistry
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“Zonal” CK5/6, P63 and Bcl-2 immunostaining, CK20+ Merker cells in lobules
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“Zonal” Bcl-2 immunostaining, CK20+ Merker cells in lobules
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Androgen receptor -, CK20+ (in some reports)
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Bcl-2 diffusely(+), No CK20+ Merker cells in tumor lobules
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PAS + clear cells
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