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Figure 2 | Diagnostic Pathology

Figure 2

From: Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases

Figure 2

Judgment for p16 immunohistochemistry (IHC) and In situ hybridization (ISH) for high- risk HPV-DNA. (A) A representative p16 IHC-positive case, showing intense nuclear and cytoplasmic staining for more than 70% of tumor cells. (B) A representative ISH positive case for high-risk HPV-DNA, showing hybridization signals visualized as punctate dots. [(A) IHC for p16, original magnification, x200, (B) ISH for HPV-DNA, original magnification, x300].

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Diagnostic Pathology

ISSN: 1746-1596

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