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Figure 1 | Diagnostic Pathology

Figure 1

From: Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature

Figure 1

Hepatosplenic CT images and histopathology. (A, B) CT scan demonstrated hepatosplenomegaly; hemorrhage was observed in splenic parenchymal and perisplenic (arrow), the largest hematoma was located under the spleen and the maximum cross-sectional area of which was 9.5 cm × 4.3 cm; ascites and enlarged lymph nodes of peritoneal cavity were also noted. (C) Histologic examination of liver showed the portal areas and sinusoidal infiltration (arrow) (H&E, original magnification × 40). (D) Neoplastic cells in the liver were monomorphic and medium size with irregular nuclei. Mitotic figures and apoptosis can be easily seen (H&E, original magnification × 400). (E) Neoplastic cells in the spleen were observed in cords and sinuses of red pulp, as well as around arteriolar sheath (H&E, original magnification × 40). (F) Neoplastic cells in the spleen were monomorphic and medium sized (H &E, original magnification × 400). (G) Necrotic areas were seen in the spleen (arrow) (H &E, original magnification × 40). (H) The blood vessel infiltration phenomenon was observed in the spleen (arrow) (H &E, original magnification × 264).

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