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Table 1 Top 20 biomarkers in the GEP-HN-LS test classification algorithm

From: A gene expression profile test to resolve head & neck squamous versus lung squamous cancers

Marker rank

Probeset ID

Gene symbol

Gene name

Tissue type with higher expression levels

1

218835_at*

SFTPA2

surfactant protein A2

Lung

2

209810_at*

SFTPB

surfactant protein B

Lung

3

37004_at*

SFTPB

surfactant protein B

Lung

4

214387_x_at*

SFTPC

surfactant protein C

Lung

5

211735_x_at*

SFTPC

surfactant protein C

Lung

6

211024_s_at*

NKX2-1

NK2 homeobox 1 (TTF-1)

Lung

7

205927_s_at

CTSE

cathepsin E

Lung

8

205654_at

C4BPA

complement component 4 binding protein, alpha

Lung

9

209351_at

KRT14

keratin 14

Head & Neck

10

205916_at

S100A7

S100 calcium binding protein A7

Head & Neck

11

205778_at

KLK7

kallikrein-related peptidase 7

Head & Neck

12

211538_s_at

HSPA2

heat shock 70 kDa protein 2

Head & Neck

13

206697_s_at

HP

haptoglobin

Lung

14

209616_s_at

CES1

carboxylesterase 1

Lung

15

211429_s_at

SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Lung

16

213553_x_at

APOC1

apolipoprotein C-I

Lung

17

204424_s_at

LMO3

LIM domain only 3 (rhombotin-like 2)

Lung

18

206008_at

TGM1

transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)

Head & Neck

19

218644_at

PLEK2

pleckstrin 2

Head & Neck

20

202017_at

EPHX1

epoxide hydrolase 1, microsomal (xenobiotic)

Lung

  1. *Known to have a role in lung biology.