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Table 3 Meta-analysis of APEX1 Asp148Glu polymorphism and breast cancer risk

From: Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis

Analysis

No. of studies

Glu/Glu vs. Asp/Asp (Homozygote)

Asp/Glu vs. Asp/Asp (Heterozygote)

Glu/Glu + Asp/Glu vs. Asp/Asp (Dominant model)

Glu/Glu vs. Asp/Glu + Asp/Asp (Recessive model)

OR (95% CI)

P/Ph

OR (95% CI)

P/ P h

OR (95% CI)

P/ P h

OR (95% CI)

P/ P h

Overall

7

0.948(0.817-1.101)

0.486/0.508

0.975(0.790-1.204)

0.814/0.028

0.959(0.803-1.146)

0.646/0.074

0.961(0.846-1.091)

0.540/0.572

Ethnicity

         

Caucasian

3

1.019(0.850-1.221)

0.842/0.395

0.928(0.670-1.285)

0.651/0.071

0.955(0.717-1.271)

0.751/0.097

1.042(0.897-1.211)

0.590/0.839

Asian

3

0.813(0.620-1.066)

0.135/0.455

1.031(0.681-1.560)

0.886/0.017

0.968(0.680-1.378)

0.855/0.035

0.873(0.604-1.091)

0.142/0.847

African

1

0.948(0.817-1.101)

0.794/—

0.870(0.404-1.870)

0.720/—

0.870(0.426-1.774)

0.701/—

0.933(0.353-2.469)

0.889/—

Menopausal status

         

Premenopausal

2

0.895(0.662-1.209)

0.469/0.509

0.938(0.744-1.181)

0.584/0.688

0.921(0.741-1.145)

0.460/0.602

0.927(0.716-1.201)

0.567/0.556

Postmenopausal

2

0.882(0.515-1.510)

0.648/0.096

1.046(0.847-1.290)

0.678/0.644

1.021(0.839-1.243)

0.835/0.323

0.972(0.782-1.208)

0.797/0.113

Quality score

         

>6

4

0.946(0.806-1.109)

0.491/0.351

0.999(0.760-1.313)

0.994/0.008

0.973(0.779-1.215)

0.807/0.031

0.952(0.831-1.091)

0.479/0.266

≤6

3

0.968(0.637-1.472)

0.880/0.368

0.898(0.642-1.256)

0.528/0.389

0.907(0.661-1.245)

0.547/0.303

1.024(0.719-1.456)

0.897/0.716

Source of control

         

HB

5

0.821(0.659-1.025)

0.081/0.809

0.921(0.669-1.268)

0.612/0.011

0.898(0.697-1.157)

0.405/0.055

0.864(0.709-1.052)

0.146/0.642

PB

2

1.070(0.874-1.309)

0.513/0.398

1.049(0.882-1.248)

0.589/0.538

1.055(0.896-1.242)

0.521/0.450

1.037(0.878-1.226)

0.667/0.562

HWE in controls

         

Yes

6

0.941(0.803-1.104)

0.456/0.390

0.930(0.818-1.057)

0.268/0.264

0.929(0.824-1.048)

0.232/0.258

0.989(0.864-1.132)

0.869/0.650

No

1

1.001(0.654-1.531)

0.997/—

1.345(0.904-2.162)

0.211/—

1.362(0.994-1.868)

0.055/—

0.774(0.532-1.126)

0.180/—

  1. Ph P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium.
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Diagnostic Pathology

ISSN: 1746-1596

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