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Table 3 Meta-analysis of APEX1 Asp148Glu polymorphism and breast cancer risk

From: Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis

Analysis No. of studies Glu/Glu vs. Asp/Asp (Homozygote) Asp/Glu vs. Asp/Asp (Heterozygote) Glu/Glu + Asp/Glu vs. Asp/Asp (Dominant model) Glu/Glu vs. Asp/Glu + Asp/Asp (Recessive model)
OR (95% CI) P/Ph OR (95% CI) P/ P h OR (95% CI) P/ P h OR (95% CI) P/ P h
Overall 7 0.948(0.817-1.101) 0.486/0.508 0.975(0.790-1.204) 0.814/0.028 0.959(0.803-1.146) 0.646/0.074 0.961(0.846-1.091) 0.540/0.572
Ethnicity          
Caucasian 3 1.019(0.850-1.221) 0.842/0.395 0.928(0.670-1.285) 0.651/0.071 0.955(0.717-1.271) 0.751/0.097 1.042(0.897-1.211) 0.590/0.839
Asian 3 0.813(0.620-1.066) 0.135/0.455 1.031(0.681-1.560) 0.886/0.017 0.968(0.680-1.378) 0.855/0.035 0.873(0.604-1.091) 0.142/0.847
African 1 0.948(0.817-1.101) 0.794/— 0.870(0.404-1.870) 0.720/— 0.870(0.426-1.774) 0.701/— 0.933(0.353-2.469) 0.889/—
Menopausal status          
Premenopausal 2 0.895(0.662-1.209) 0.469/0.509 0.938(0.744-1.181) 0.584/0.688 0.921(0.741-1.145) 0.460/0.602 0.927(0.716-1.201) 0.567/0.556
Postmenopausal 2 0.882(0.515-1.510) 0.648/0.096 1.046(0.847-1.290) 0.678/0.644 1.021(0.839-1.243) 0.835/0.323 0.972(0.782-1.208) 0.797/0.113
Quality score          
>6 4 0.946(0.806-1.109) 0.491/0.351 0.999(0.760-1.313) 0.994/0.008 0.973(0.779-1.215) 0.807/0.031 0.952(0.831-1.091) 0.479/0.266
≤6 3 0.968(0.637-1.472) 0.880/0.368 0.898(0.642-1.256) 0.528/0.389 0.907(0.661-1.245) 0.547/0.303 1.024(0.719-1.456) 0.897/0.716
Source of control          
HB 5 0.821(0.659-1.025) 0.081/0.809 0.921(0.669-1.268) 0.612/0.011 0.898(0.697-1.157) 0.405/0.055 0.864(0.709-1.052) 0.146/0.642
PB 2 1.070(0.874-1.309) 0.513/0.398 1.049(0.882-1.248) 0.589/0.538 1.055(0.896-1.242) 0.521/0.450 1.037(0.878-1.226) 0.667/0.562
HWE in controls          
Yes 6 0.941(0.803-1.104) 0.456/0.390 0.930(0.818-1.057) 0.268/0.264 0.929(0.824-1.048) 0.232/0.258 0.989(0.864-1.132) 0.869/0.650
No 1 1.001(0.654-1.531) 0.997/— 1.345(0.904-2.162) 0.211/— 1.362(0.994-1.868) 0.055/— 0.774(0.532-1.126) 0.180/—
  1. Ph P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium.