Figure 4

Histologic appearance of well differentiated SCC (H & E). Differentiation of basal cells to keratinocytes is still present. A concentric aggregation of cornfield squamous epithelial cells (Note the prominent keratin pearl formation; blue arrow) is visible with pleomorphism of nuclei, rare mitotic figures and giant nucleus formation and also, the cells had distinct borders, ranged from polygonal to round or elongate, and had moderate amounts of eosinophilic cytoplasm furthermore, the sub-epidermis is focally thickened by large keratinocytes containing increased quantities of pale white cytoplasm that is variably vacuolated HE. ×400.