Figure 3
From: Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
Post-treatment radiological analyses of the left knee. Plain radiographs show marked osteosclerosis and sclerotic rim formation on both the proximal tibial tumor (A, B) and distal femoral tumors. MRI shows a tumor displaying iso-intensity to the surrounding muscle on T1-weighted imaging (coronal view) (C), heterogeneous high intensity (but lower than at pretreatment) on T2-weighted imaging (axial view) (D), and diffuse enhancement on gadolinium-enhanced T1-weighted fat-suppression imaging (coronal view) (E). 18F-FDG PET/CT revealed the marginal/intralesional osteosclerosis of the proximal tibial tumor (F) with markedly decreased SUV uptake (SUVmax: 4.8 in the tibial tumor) (G).