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Table 3 Meta-analysis of XPC Lys939Gln polymorphism and colorectal cancer risk

From: XPC Lys939Gln polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis

Analysis No. of studies Homozygote Heterozygote Dominant model Recessive model
(Gln/Gln vs. Lys/Lys) (Gln/lys vs. Lys/Lys) (Gln/Gln + Gln/lys vs. Lys/Lys) (Gln/Gln vs. Gln/lys + Lys/Lys)
OR (95% CI) P/P Q OR (95% CI) P/P Q OR (95% CI) P/P Q OR (95% CI) P/P Q
Overall 8 1.134(0.979-1.315) 0.094/0.495 1.293(1.169-1.430) 0.000/0.943 1.260(1.145-1.388) 0.000/0.955 0.976(0.853-1.117) 0.722/0.211
Ethnicity          
Caucasian 4 1.038(0.818-1.318) 0.758/0.885 1.200(0.983-1.426) 0.098/0.918 1.159(0.984-1.365) 0.077/0.951 0.915(0.740-1.133) 0.417/0.644
Asian 4 1.199(0.993-1.446) 0.059/0.180 1.345(1.187-1.523) 0.000/0.878 1.317(1.170-1.484) 0.000/0.978 1.078(0.809-1.436) 0.607/0.061
Source of control          
HB 6 1.091(0.915-1.302) 0.333/0.399 1.335(1.182-1.507) 0.000/0.961 1.282(1.142-1.439) 0.000/0.945 0.922(0.785-1.082) 0.318/0.184
PB 2 1.243(0.950-1.627) 0.112/0.440 1.204(1.003-1.444) 0.046/0.528 1.213(1.020-1.443) 0.029/0.436 1.122(0.875-1.438) 0.366/0.545
Cancer location          
Colon 2 1.105(0.809-1.510) 0.528/0.327 1.278(0.983-1.601) 0.093/0.851 1.234(0.996-1.528) 0.054/0.826 0.953(0.719-1.264) 0.738/0.226
Rectum 2 1.253(0.902-1.741) 0.179/0.482 1.200(0.941-1.532) 0.142/0.471 1.217(0.967-1.531) 0.094/0.419 1.140(0.847-1.534) 0.388/0.643
Smoking          
Yes 3 1.299(0.841-2.006) 0.237/0.169 1.164(0.871-1.556) 0.305/0.825 1.118(0.900-1.389) 0.314/0.455 1.185(0.794-1.770) 0.405/0.261
No 2 1.256(0.620-2.542) 0.527/— 1.284(0.817-2.018) 0.279/— 1.286(1.020-1.622) 0.033/0.972 1.117(0.570-2.187) 0.747/—
Study quality          
High quality 4 1.093(0.920-1.299) 0.313/0.547 1.290(1.148-1.450) 0.000/0.531 1.248(1.117-1.395) 0.000/0.680 0.950(0.811-1.114) 0.530/0.310
Low quality 4 1.257(0.944-1.674) 0.118/0.304 1.201(0.963-1.563) 0.091/0.996 1.278(0.971-1.552) 0.108/0.929 1.046(0.809-1.353) 0.733/0.128
  1. PQ P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HWE, Hardy–Weinberg equilibrium.