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Table 3 Meta-analysis of XPC Lys939Gln polymorphism and colorectal cancer risk

From: XPC Lys939Gln polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis

Analysis

No. of studies

Homozygote

Heterozygote

Dominant model

Recessive model

(Gln/Gln vs. Lys/Lys)

(Gln/lys vs. Lys/Lys)

(Gln/Gln + Gln/lys vs. Lys/Lys)

(Gln/Gln vs. Gln/lys + Lys/Lys)

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

Overall

8

1.134(0.979-1.315)

0.094/0.495

1.293(1.169-1.430)

0.000/0.943

1.260(1.145-1.388)

0.000/0.955

0.976(0.853-1.117)

0.722/0.211

Ethnicity

         

Caucasian

4

1.038(0.818-1.318)

0.758/0.885

1.200(0.983-1.426)

0.098/0.918

1.159(0.984-1.365)

0.077/0.951

0.915(0.740-1.133)

0.417/0.644

Asian

4

1.199(0.993-1.446)

0.059/0.180

1.345(1.187-1.523)

0.000/0.878

1.317(1.170-1.484)

0.000/0.978

1.078(0.809-1.436)

0.607/0.061

Source of control

         

HB

6

1.091(0.915-1.302)

0.333/0.399

1.335(1.182-1.507)

0.000/0.961

1.282(1.142-1.439)

0.000/0.945

0.922(0.785-1.082)

0.318/0.184

PB

2

1.243(0.950-1.627)

0.112/0.440

1.204(1.003-1.444)

0.046/0.528

1.213(1.020-1.443)

0.029/0.436

1.122(0.875-1.438)

0.366/0.545

Cancer location

         

Colon

2

1.105(0.809-1.510)

0.528/0.327

1.278(0.983-1.601)

0.093/0.851

1.234(0.996-1.528)

0.054/0.826

0.953(0.719-1.264)

0.738/0.226

Rectum

2

1.253(0.902-1.741)

0.179/0.482

1.200(0.941-1.532)

0.142/0.471

1.217(0.967-1.531)

0.094/0.419

1.140(0.847-1.534)

0.388/0.643

Smoking

         

Yes

3

1.299(0.841-2.006)

0.237/0.169

1.164(0.871-1.556)

0.305/0.825

1.118(0.900-1.389)

0.314/0.455

1.185(0.794-1.770)

0.405/0.261

No

2

1.256(0.620-2.542)

0.527/—

1.284(0.817-2.018)

0.279/—

1.286(1.020-1.622)

0.033/0.972

1.117(0.570-2.187)

0.747/—

Study quality

         

High quality

4

1.093(0.920-1.299)

0.313/0.547

1.290(1.148-1.450)

0.000/0.531

1.248(1.117-1.395)

0.000/0.680

0.950(0.811-1.114)

0.530/0.310

Low quality

4

1.257(0.944-1.674)

0.118/0.304

1.201(0.963-1.563)

0.091/0.996

1.278(0.971-1.552)

0.108/0.929

1.046(0.809-1.353)

0.733/0.128

  1. PQ P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HWE, Hardy–Weinberg equilibrium.
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Diagnostic Pathology

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