Skip to main content

Table 1 Characteristics of the case–control studies in the current meta-analyses

From: Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

Gene locus First author Year Country Ethnicity Genotyping method Cases/controls Control source HWE Result* Power MAF
TAP2-379 B. P. Wordsworth [14] 1993 Britain Europeans ARMS-PCR 60/117 Population NA NS 0.101 0.167
  Sara Marsal [15] 1994 America Europeans ARMS-PCR 185/48 Population NA NS 0.086 0.177
  M.C. Hillarby [16] 1996 Britain Europeans ARMS-PCR 89/64 Population NA S 0.091 0.172
  F. Takeuchi [17] 1997 Japan Asians PCR-RFLP 92/95 Population NA NS 0.095 0.132
  J Vinasco [18] 1998 Spain Europeans PCR-RFLP 50/55 Population NA NS 0.072 0.109
  Sasijit Vejbaesya [19] 2000 Thailand Asians ARMS-PCR 82/100 Population Yes NS 0.115 0.220
  S.-L. Zhang [20] 2002 France Europeans ARMS-PCR 138/100 Population Yes NS 0.098 0.120
  Min-Chien Yu [21] 2004 China Asians PCR-RFLP 100/99 Population Yes NS 0.124 0.237
TAP2-565 B. P. Wordsworth [14] 1993 Britain Europeans ARMS-PCR 60/117 Population NA NS 0.094 0.132
  Sara Marsal [15] 1994 America Europeans ARMS-PCR 185/48 Population NA NS 0.081 0.156
  M.C. Hillarby [16] 1996 Britain Europeans ARMS-PCR 89/64 Population NA NS 0.086 0.148
  F. Takeuchi [17] 1997 Japan Asians PCR-RFLP 92/95 Population NA S 0.09 0.116
  J Vinasco [18] 1998 Spain Europeans PCR-RFLP 50/55 Population NA NS 0.059 0.036
  S.-L. Zhang [20] 2002 France Europeans ARMS-PCR 138/100 Population Yes S 0.078 0.070
  Min-Chien Yu [21] 2004 China Asians PCR-RFLP 100/99 Population Yes NS 0.086 0.096
  Yu L [22] 2013 China Asians PCR-RFLP 177/288 Population Yes NS 0.169 0.142
TAP2-665 B. P. Wordsworth [14] 1993 Britain Europeans ARMS-PCR 60/117 Population NA NS 0.115 0.248
  Sara Marsal [15] 1994 America Europeans ARMS-PCR 185/48 Population NA NS 0.084 0.167
  M.C. Hillarby [16] 1996 Britain Europeans ARMS-PCR 89/64 Population NA NS 0.119 0.375
  F. Takeuchi [17] 1997 Japan Asians PCR-RFLP 92/95 Population NA NS 0.136 0.347
  J Vinasco [18] 1998 Spain Europeans PCR-RFLP 50/55 Population NA NS 0.091 0.264
  Juha Tuokko [23] 1998 Finland Europeans PCR-RFLP 40/60 Population No NS 0.095 0.350
  S.-L. Zhang [20] 2002 France European ARMS-PCR 138/100 Population Yes NS 0.148 0.300
  Min-Chien Yu [21] 2004 China Asians PCR-RFLP 100/99 Population Yes NS 0.147 0.601*
  1. ARMS-PCR: Amplification refractory mutation system; PCR-RFLP: Polymerase Chain Reaction –Restriction Fragment Length Polymorphism; HWE.
  2. Hardy-Weinberg equilibrium; Result*, The association between IL1B gene and PD; NS, No significant; S, Significant; NA: Not applicable; *The reference allele is TAP2-665Ala.