Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

Dai, Dongjun; Chen, Yong; Ru, Ping; Zhou, Xingyu; Tao, Jianmin; Ye, Huadan; Hong, Qingxiao; Tang, Linlin; Pan, Guanghui; Lin, Danfeng; Gong, Qiongyao; Lv, Yuelong; Xu, Leiting; Duan, Shiwei

doi:10.1186/1746-1596-9-129

Diagnostic Pathology

Table 1 Characteristics of the case–control studies in the current meta-analyses

From: Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

Gene locus	First author	Year	Country	Ethnicity	Genotyping method	Cases/controls	Control source	HWE	Result*	Power	MAF
TAP2-379	B. P. Wordsworth [14]	1993	Britain	Europeans	ARMS-PCR	60/117	Population	NA	NS	0.101	0.167
	Sara Marsal [15]	1994	America	Europeans	ARMS-PCR	185/48	Population	NA	NS	0.086	0.177
	M.C. Hillarby [16]	1996	Britain	Europeans	ARMS-PCR	89/64	Population	NA	S	0.091	0.172
	F. Takeuchi [17]	1997	Japan	Asians	PCR-RFLP	92/95	Population	NA	NS	0.095	0.132
	J Vinasco [18]	1998	Spain	Europeans	PCR-RFLP	50/55	Population	NA	NS	0.072	0.109
	Sasijit Vejbaesya [19]	2000	Thailand	Asians	ARMS-PCR	82/100	Population	Yes	NS	0.115	0.220
	S.-L. Zhang [20]	2002	France	Europeans	ARMS-PCR	138/100	Population	Yes	NS	0.098	0.120
	Min-Chien Yu [21]	2004	China	Asians	PCR-RFLP	100/99	Population	Yes	NS	0.124	0.237
TAP2-565	B. P. Wordsworth [14]	1993	Britain	Europeans	ARMS-PCR	60/117	Population	NA	NS	0.094	0.132
	Sara Marsal [15]	1994	America	Europeans	ARMS-PCR	185/48	Population	NA	NS	0.081	0.156
	M.C. Hillarby [16]	1996	Britain	Europeans	ARMS-PCR	89/64	Population	NA	NS	0.086	0.148
	F. Takeuchi [17]	1997	Japan	Asians	PCR-RFLP	92/95	Population	NA	S	0.09	0.116
	J Vinasco [18]	1998	Spain	Europeans	PCR-RFLP	50/55	Population	NA	NS	0.059	0.036
	S.-L. Zhang [20]	2002	France	Europeans	ARMS-PCR	138/100	Population	Yes	S	0.078	0.070
	Min-Chien Yu [21]	2004	China	Asians	PCR-RFLP	100/99	Population	Yes	NS	0.086	0.096
	Yu L [22]	2013	China	Asians	PCR-RFLP	177/288	Population	Yes	NS	0.169	0.142
TAP2-665	B. P. Wordsworth [14]	1993	Britain	Europeans	ARMS-PCR	60/117	Population	NA	NS	0.115	0.248
	Sara Marsal [15]	1994	America	Europeans	ARMS-PCR	185/48	Population	NA	NS	0.084	0.167
	M.C. Hillarby [16]	1996	Britain	Europeans	ARMS-PCR	89/64	Population	NA	NS	0.119	0.375
	F. Takeuchi [17]	1997	Japan	Asians	PCR-RFLP	92/95	Population	NA	NS	0.136	0.347
	J Vinasco [18]	1998	Spain	Europeans	PCR-RFLP	50/55	Population	NA	NS	0.091	0.264
	Juha Tuokko [23]	1998	Finland	Europeans	PCR-RFLP	40/60	Population	No	NS	0.095	0.350
	S.-L. Zhang [20]	2002	France	European	ARMS-PCR	138/100	Population	Yes	NS	0.148	0.300
	Min-Chien Yu [21]	2004	China	Asians	PCR-RFLP	100/99	Population	Yes	NS	0.147	0.601*

ARMS-PCR: Amplification refractory mutation system; PCR-RFLP: Polymerase Chain Reaction –Restriction Fragment Length Polymorphism; HWE.
Hardy-Weinberg equilibrium; Result*, The association between IL1B gene and PD; NS, No significant; S, Significant; NA: Not applicable; *The reference allele is TAP2-665Ala.

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ISSN: 1746-1596

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