Adrenal cortical carcinoma with extension into the inferior vena cava – case report and literature review

Diagnostic Pathology

Table 3 Van Slooten criteria for distinguishing a malignant adrenal cortical neoplasm from a benign one[18]

Van slooten criteria	Value	Our case (“+” = presence; “-” = absence)
Regressive changes (necrosis, haemorrhage, fibrosis, calcification)	5.7	+
Lack of normal structure	1.6	+
Moderate to marked nuclear atypia	2.1	+
Nuclear hyperchromasia	2.6	+
Abnormal nucleoli	4.1	+
MI (mitotic index) >2/10 HPF	9.0	+
Capsular/vascular invasion	3.3	+
Total Van Slooten score		28.4

ISSN: 1746-1596