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Table 2 Statistics of the 24 dysregulated proteins in colorectal cancer compared with health individuals

From: Identification alpha-2-HS-glycoprotein precursor and tubulin beta chain as serology diagnosis biomarker of colorectal cancer

Mass

Colorectal cancerâ–²

Health volunteerâ–²

Regulation in colorectal cancer

P-value★

 

(Average ± SD)

(Average ± SD)

  

1618.52※

64.84 ± 37

20.91 ± 17.59

Up-regulation

0.001

1467.44※

52 ± 36.99

12.41 ± 6.73

Up-regulation

0.000

4214.69※

45.08 ± 24.84

100.83 ± 26.97

Down-regulation

0.000

798.20

41.9 ± 26.18

17.04 ± 6.00

Up-regulation

0.004

825.73

25.51 ± 16.96

11.25 ± 3.07

Up-regulation

0.007

651.55

16.05 ± 15.27

30.14 ± 14.65

Down-regulation

0.007

1656.22※

13.77 ± 7.10

4.69 ± 2.63

Up-regulation

0.000

667.29

12.34 ± 9.65

19.76 ± 8.55

Down-regulation

0.028

1505.47※

10.81 ± 5.89

3.86 ± 1.18

Up-regulation

0.000

1521.72

10.49 ± 4.50

5.20 ± 2.38

Up-regulation

0.002

1208.30※

10.39 ± 4.48

4.27 ± 1.05

Up-regulation

0.001

1867.23

10.00 ± 6.35

17.64 ± 7.03

Down-regulation

0.018

1585.25

9.64 ± 3.93

5.51 ± 2.48

Up-regulation

0.004

4096.50

7.39 ± 4.77

14.26 ± 3.80

Down-regulation

0.005

1780.03

6.90 ± 5.09

11.21 ± 5.26

Down-regulation

0.019

7791.73

6.43 ± 6.97

13.01 ± 3.03

Down-regulation

0.014

4058.71

3.59 ± 2.73

15.02 ± 6.18

Down-regulation

0.000

4198.23

3.53 ± 2.77

7.44 ± 2.62

Down-regulation

0.003

4271.61

2.04 ± 1.71

4.64 ± 1.51

Down-regulation

0.000

4174.45

1.53 ± 1.25

2.63 ± 1.07

Down-regulation

0.021

4177.42

1.50 ± 1.25

2.51 ± 1.13

Down-regulation

0.026

4079.82

1.45 ± 1.04

2.49 ± 0.91

Down-regulation

0.014

4076.90

1.43 ± 1.04

2.57 ± 0.87

Down-regulation

0.007

3939.53

1.08 ± 0.51

1.88 ± 0.68

Down-regulation

0.005

  1. ※The peptide selected for model construction.
  2. â–² Peak area.
  3. ★P value calculated with the Wilcoxon test; values lower than 0.05 suggest statistical relevance.