Table 3 Meta-analysis of the TNF-α gene polymorphisms on prostate cancer risk

TNF-α-308G/A

AA vs. GG

Overall

14

0.936

0.733-1.195

0.595

F

16.20

19.8

0.238

Caucasia

8

0.762

0.569-1.021

0.068

F

5.68

0.0

0.461

Asia

3

1.558

0.620-3.419

0.346

F

4.29

30.1

0.231

Mix

2

1.616

0.917-2.848

0.097

F

0.11

0.0

0.736

African-American

1

1.119

0.181-6.903

0.904

-

-

-

-

PB

5

0.886

0.660-1.190

0.422

F

6.72

40.5

0.152

HB

7

0.924

0.557-1.481

0.743

F

6.76

11.2

0.344

HV

2

2.861

0.732-11.181

0.131

F

0.00

0.0

0.979

AG vs. GG

Overall

14

1.105

0.932-1.309

0.251

R

41.38

68.6

<0.001

Caucasia

7

1.234

0.965-1.600

0.092

R

31.63

81.0

<0.001

Asia

4

0.928

0.699-1.234

0.608

F

4.12

27.2

0.249

Mix

2

1.065

0.882-1.288

0.512

F

0.70

0.0

0.404

African-American

1

0.458

0.204-1.027

0.058

-

-

-

-

PB

5

0.997

0.899-1.106

0.958

F

3.39

0.0

0.495

HB

7

1.174

0.709-1.746

0.428

R

32.78

81.7

<0.001

HV

2

1.477

1.047-2.085

0.026

F

0.27

0.0

0.602

AA + AG vs. GG

Overall

14

1.103

0.932-1.306

0.254

R

43.71

70.3

<0.001

Caucasia

8

1.206

0.941-1.545

0.138

R

32.21

81.4

<0.001

Asia

3

1.008

0.657-1.547

0.97

R

6.83

56.1

0.078

Mix

2

1.101

0.916-1.323

0.304

F

0.63

0.0

0.429

African-American

1

0.513

0.242-1.088

0.082

-

-

-

-

PB

5

0.987

0.892-1.091

0.799

F

4.96

19.4

0.291

HB

7

1.174

0.803-1.719

0.408

R

32.22

81.4

<0.001

HV

2

1.531

1.093-2.145

0.013

F

0.24

0.0

0.628

AA vs. GG + AG

Overall

14

0.92

0.721-1.172

0.502

F

16.2

19.7

0.239

Caucasia

7

0.748

0.559-1.001

0.051

F

5.93

0.0

0.431

Asia

4

1.559

0.618-3.935

0.347

F

3.98

24.7

0.263

Mix

2

1.569

0.893-2.757

0.117

F

0.19

0.0

0.660

African-American

1

1.303

0.212-7.991

0.775

-

-

-

-

PB

5

0.883

0.659-1.184

0.407

F

6.26

36.1

0.181

HB

7

0.886

0.555-1.413

0.611

F

7.49

19.9

0.278

HV

2

2.65

0.679-10.341

0.161

F

0.00

0.0

0.997

TNF-α-238G/A

AA vs. GG

Overall

4

1.09

0.403-2.943

0.866

F

4.61

34.9

0.203

Caucasia

3

1.29

0.436-3.816

0.645

F

4.35

54.1

0.113

African-American

1

0.391

0.018-8.288

0.547

-

-

-

-

HB

3

1.579

0.492-5.071

0.442

F

3.750

46.7

0.153

PB

1

0.344

0.036-3.310

0.355

-

-

-

-

AG vs. GG

Overall

5

1.07

0.680-1.683

0.77

R

12.49

68.0

0.014

Caucasia

3

1.284

0.841-2.025

0.282

R

5.99

66.6

0.050

Asia

1

0.431

0.200-0.931

0.032

-

-

-

-

African-American

1

1.179

0.408-3.405

0.706

-

-

-

-

HB

4

1.008

0.506-2.010

0.981

R

11.3

73.4

0.01

PB

1

1.248

0.944-1.649

0.12

-

-

-

-

AA + AG vs. GG

Overall

5

1.06

0.713-1.575

0.774

R

9.95

59.8

0.041

Caucasia

3

1.226

0.982-1.531

0.072

F

3.33

39.9

0.189

Asia

1

0.431

0.200-0.931

0.032

-

-

-

-

African-American

1

0.983

0.351-2.752

0.974

-

-

-

-

HB

4

0.984

0.535-1.808

0.958

R

9.170

67.3

0.027

PB

1

1.221

0.926-1.610

0.156

-

-

-

-

AA vs. GG + AG

Overall

4

1.036

0.388-2.767

0.943

F

4.9

38.2

0.182

Caucasia

3

0.892

0.084-9.494

0.925

R

4.63

56.8

0.099

African-American

1

0.386

0.018-8.161

0.541

-

-

-

-

HB

3

1.468

0.467-4.615

0.511

F

4.050

50.6

0.132

PB

1

0.336

0.035-3.238

0.346

-

-

-

-