Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma

Table 4 Five year overall survival in relation to margin status in the original reports and after re-evaluation

	Margin status in original reports				Margin status after re-evaluation
	Number	Median OS (IQR)	Unadjusted HR (95% CI)	Adjusted HR (95% CI)	Number	Median OS (IQR)	Unadjusted HR (95% CI)	Adjusted HR (95% CI)
R0	90	36.3 (23.1 - n.r.)			25	n.r. (35.0 - n.r.)
Rx					54	40.2 (24.0 - n.r.)	2.3 (1.0 - 5.2)	2.2 (1.0 - 4.9)
R1	69	25.1 (14.0 - 46.3)	1.6 (1.1 - 2.4)	1.0 (0.7 - 1.6)	93	25.4 (14.6 - 41.6)	3.3 (1.5 - 7.0)

Hazard ratios (HR) for risk of death within 5 years in relation to margin status, with R0 as reference. OS in the re-evaluated R0-group was significantly better than in the original report R0-group (p < 0.001). Differences in OS between the three levels of margin status in the re-evaluated material were significant; R0 vs R1 (p < 0.001), R1 vs Rx (p = 0.005) and R0 vs Rx (p = 0.043). HR for both original report and re-evaluated margin status adjusted for re-evaluated parameters.
R0, uninvolved margins. Rx, uncertain margin status. R1, cancer less than 1 mm from margin. IQR, interquartile range. CI, confidence interval. N.r., not reached.

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