Table 5 Unadjusted and adjusted hazard ratios for death within 5 years in relation to re-evaluated histopathology parameters
n (events) | Unadjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
|---|---|---|---|---|---|
Age, continuous | 172 (112) | 1.0 (1.0-1.0) | 0.479 | 1.0 (1.0-1.1) | 0.015 |
Sex | |||||
Female | 86 (47) | ||||
Male | 86 (65) | 1.5 (1.0-2.2) | 0.042 | 1.4 (0.9-2.0) | 0.131 |
T-stage | |||||
T1 | 8 (3) | ||||
T2 | 23 (12) | 1.5 (0.4-5.2) | 0.553 | 1.1 (0.3-4.4) | 0.847 |
T3 | 102 (66) | 2.7 (0.8-8.6) | 0.995 | 1.0 (0.3-3.8) | 0.948 |
T4 | 39 (31) | 3.4 (1.0-11.2) | 0.043 | 1.3 (0.3-5.1) | 0.683 |
N-stage | |||||
N0 | 67 (37) | ||||
N1-N2 | 105 (75) | 2.0 (1.3-2.9) | 0.001 | 1.3 (0.8-2.0) | 0.265 |
Tumour size, continuous | 172 (112) | 1.0 (1.0-1.0) | 0.010 | 1.0 (1.0-1.0) | 0.533 |
Tumour differentiation | |||||
Well-moderate | 73 (38) | ||||
Poor | 99 (74) | 2.3 (1.5-3.3) | <0.001 | 1.9 (1.2-2.8) | 0.002 |
Tumour morphology | |||||
Intestinal type | 63 (31) | ||||
Pancreatobiliary type | 109 (81) | 2.3 (1.5-3.4) | <0.001 | 1.3 (0.7-2.3) | 0.394 |
Margins | |||||
R0 | 25 (7) | ||||
R1-Rx | 147 (105) | 3.3 (1.5-7.0) | 0.002 | 2.2 (1.0-4.9) | 0.046 |
Perineural growth | |||||
No | 68 (33) | ||||
Yes | 104 (79) | 2.4 (1.6-3.7) | <0.001 | 1.1 (0.6-1.8) | 0.779 |
Growth in lymphatic vessels | |||||
No | 63 (30) | ||||
Yes | 109 (82) | 2.2 (1.4-3.3) | <0.001 | 1.2 (0.8-1.9) | 0.420 |
Growth in blood vessels | |||||
No | 131 (74) | ||||
Yes | 41 (38) | 3.1 (2.1-4.7) | <0.001 | 2.4 (1.6-3.7) | <0.001 |
Growth in peripancreatic fat | |||||
No | 67 (30) | ||||
Yes | 105 (82) | 2.8 (1.8-4.3) | <0.001 | 2.1 (1.4-3.3) | 0.001 |