Figure 1
From: Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance
mRNA expression of mdr1, MRP1 and BCRP. mRNA expression measured by real time PCR of A) mdr1, B) MRP1 and C) BCRP in drug resistant cells and the respective parental cells normalized to GAPDH mRNA expression. mRNA expression of mdr1 is significantly higher in all Doxorubicin resistant cells (MCF-7 and SaOS2). No significant increase in mdr1 expression by Cisplatin resistant A2780 was observed.