Figure 2
From: Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance
mRNA and protein expression of Sirt7. A) mRNA expression of Sirt7 normalized to GAPDH mRNA expression by RT-PCR, where the expression of Sirt7 is reduced in all chemoresistant cell lines tested (MCF-7, SaOS2, and A2780); B) A representative Western blot for Sirt7 protein expression showing a significant reduction of Sirt7 expression in all drug-resistant cells (MCF-7, SaOS2, and A2780); C) Densitometric quantitation of Sirt7/β-actin protein expression ratio.