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Table 2 Multivariate analyses for relapse-free survival and overall survival by Cox regression model

From: Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer

  Relapse-free survival Overall survival
Variable Hazard ratio 95% CI P-value Hazard ratio 95% CI P-value
Age 1.06 0.23-2.35 0.57 1.21 0.35-1.30 0.23
TNM stage 3.29 0.89-7.23 0.06 4.24 3.21-9.22 0.01*
Tumor grade 2.98 1.29-6.77 0.009* 3.83 0.87-4.91 0.08
Histological type 0.81 0.27-3.23 0.62 0.91 0.37-1.29 0.36
Lymph node metastasis 2.21 0.98-8.22 0.07 3.12 2.46-10.92 0.007*
ER 1.28 0.82-2.33 0.29 1.81 0.23-3.11 0.63
PR 1.87 0.28-2.99 0.32 1.34 0.38-3.10 0.29
HER2 2.29 1.88-4.83 0.02* 2.12 0.91-3.91 0.06
DKK-1 expression 3.97 1.82-10.99 <0.001* 2.19 1.28-9.24 0.002*
  1. *Statistically significant.
  2. ER = estrogen receptor; PR = progesterone receptor; HER-2 = c-erb B-2.