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Table 1 The clinical presentations and pathological features of three intraductal neoplasms of pancreas

From: Intraductal tubular adenomas (pyloric gland-type) of the pancreas: clinicopathologic features are similar to gastric-type intraductal papillary mucinous neoplasms and different from intraductal tubulopapillary neoplasms

  Gastric-type IPMN ITA ITPN
Gender (M/F) 10/6 5/2 2/4
Age (average age) 39-78 (61) 47-74 (58) 48-70 (64)
Site (head/body/tail) 10/3/3 4/3/0 4/1/1
Clinical features
Symptoms 8/5/3 4/2/1 (back pain) 4/1/1 (jaundice)
Chronic pancreatitis 5/16 4/7 2/6
Diabetes mellitus 4/16 1/7 3/6
Chronic use of tobacco 6/16 3/7 2/6
CA-199 elevated in blood 5/16 1/7 2/6
CEA elevated in blood 2/16 0/7 0/6
Pathological features
Diameter 1-6 cm 0.6-3 cm 1.5-4.5 cm
Microscopic features Papillary growth with large mucin Tubulopapillary growth with mucin Tubulopapillary growth without luminal mucin
Immunohistochemistry
MUC5AC 16/16 7/7 3/6
MUC1 0/16 0/7 3/6
MUC2 9/16 (goblet cells) 3/7 (goblet cells) 0
Ki-67 index <1% 2/7 3-5% >20%
P53 - - 3/6
KRAS mutation 9/16 (56%) 4/7 (57%) 2/6 (33%)
  1. From left to right: abdominal discomfort/routine checkup/other symptoms, such as jaundice, back pain, et al.