Table 1 The clinical presentations and pathological features of three intraductal neoplasms of pancreas

Gender (M/F)

10/6

5/2

2/4

Age (average age)

39-78 (61)

47-74 (58)

48-70 (64)

Site (head/body/tail)

10/3/3

4/3/0

4/1/1

Symptoms^※

8/5/3

4/2/1 (back pain)

4/1/1 (jaundice)

Chronic pancreatitis

5/16

4/7

2/6

Diabetes mellitus

4/16

1/7

3/6

Chronic use of tobacco

6/16

3/7

2/6

CA-199 elevated in blood

5/16

1/7

2/6

CEA elevated in blood

2/16

0/7

0/6

Diameter

1-6 cm

0.6-3 cm

1.5-4.5 cm

Microscopic features

Papillary growth with large mucin

Tubulopapillary growth with mucin

Tubulopapillary growth without luminal mucin

MUC5AC

16/16

7/7

3/6

MUC1

0/16

0/7

3/6

MUC2

9/16 (goblet cells)

3/7 (goblet cells)

0

Ki-67 index

<1%

2/7 3-5%

>20%

P53

-

-

3/6

KRAS mutation

9/16 (56%)

4/7 (57%)

2/6 (33%)