Table 3 Frequencies of several abnormalities detected in non-clonal cytopenias and MDS
Alterations | Reactive cytopenias (n = 35) | MDS low risk <5%BM blast (n = 42) | MDS high risk >5% BM blast (n = 12) | p value for X 2 |
|---|---|---|---|---|
Granulocytic series | Â | Â | Â | Â |
Abnormal granularity | 0 | 17 | 3 | 0.001 |
Abnormal decrease in CD45 expression | 3 | 9 | 1 | 0.245 |
Abnormal pattern in CD13/CD16 | 2 | 23 | 8 | 0.0001 |
Abnormal pattern in CD33/HLA-DR | 7 | 26 | 9 | 0.0001 |
Expression of CD56 | 0 | 9 | 1 | 0.018 |
Aberrant expression of CD34 | 1 | 7 | 3 | 0.06 |
Aberrant expression of CD7 | 1 | 2 | 1 | 0.776 |
Aberrant expression of CD19 | 0 | 4 | 0 | 0.101 |
Asynchronous shift to the left | 7 | 11 | 6 | 0,227 |
Monocytes series | Â | Â | Â | Â |
Abnormal granularity | 7 | 12 | 0 | 0.10 |
Abnormal % Monocytes | 11 | 27 | 9 | 0.04 |
Increase of % Monocytes CD16+ | 8 | 19 | 8 | 0.015 |
Abnormal pattern in CD33/HLA-DR | 5 | 21 | 2 | 0.01 |
Expression of CD56 | 6 | 14 | 3 | 0.20 |
Aberrant expression of CD34 | 1 | 17 | 6 | <0.0001 |
Aberrant expression of CD7 | 1 | 9 | 5 | 0.008 |
Aberrant expression of CD19 | 1 | 5 | 2 | 0.278 |
Cells in the blast gate | Â | Â | Â | Â |
Increase of % CD34+ cells | 1 | 11 | 10 | <0.0001 |
Increase of % CD34+/CD13+/CD117+ | 4 | 18 | 9 | 0.001 |
Anomalous expression of CD7 | 0 | 9 | 8 | <0.0001 |
Anomalous expression of CD56 | 2 | 15 | 9 | <0.0001 |