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Table 3 Comparison between RB1 / CDH1 methylation and HPV/EBV infection, reporting the percentages of methylated cases among HPV/EBV positive cases

From: Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study

Control/Lesion Type Methylation Status
RB1 CDH1
HPV+, n (%)* EBV+, n (%) HPV and EBV+, n (%) HPV and EBV-, n (%) HPV+, n (%) EBV+, n (%)** HPV and EBV+, n (%) HPV and EBV-, n (%)
Control (n = 15) 0 (0.0) 0 (0.0) 0 (0.0) 1 (20.0) 1 (25.0) 0 (0.0) 0 (0.0) 1 (20.0)
LSIL (n = 17) 1 (9.1) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (15.3) 0 (0.0) 0 (0.0)
HSIL (n = 15) 4 (50.0) 0 (0.0) 0 (0.0) 0 (0.0) 4 (50.0) 2 (28.6) 2 (50.0) 0 (0.0)
Cancer (n = 18) 7 (50.0) 7 (63.6) 6 (60.0) 1 (33.3) 4 (28.6) 5 (45.5) 4 (40.0) 1 (33.3)
Total (n = 65) 12 (32.4) 7 (17.9) 6 (25.0) 2 (15.3) 9 (24.3) 9 (23.1) 6 (25.0) 2 (15.3)
  1. * p  = 0.0421 (LSIL versus Cancer).
  2. ** p  = 0.1819 (LSIL versus Cancer).
  3. +, presence; -, absence; LSIL, low-grade squamous intraepithelial lesions; HSIL, high-grade squamous intraepithelial lesions.
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Diagnostic Pathology

ISSN: 1746-1596

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