Table 2 Univariate and multivariate analysis of prognostic factors in 112 CRC patients for overall survival
From: High Rab27A expression indicates favorable prognosis in CRC
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
HR | p value | 95 % CI | HR | p value | 95 % CI | |
Rab27A protein expression | ||||||
High versus Low or no | 0.33 | 0.001* | 0.181–0.616 | 0.36 | 0.012* | 0.159–0.794 |
Gender | ||||||
Male versus Female | 1.43 | 0.277 | 0.750–2.726 | |||
Age (years) | ||||||
≥60 versus <60 | 1.16 | 0.642 | 0.618–2.184 | |||
Tumor size (cm) | ||||||
≥5 versus <5 | 1.21 | 0.537 | 0.659–2.224 | |||
Tumor location | ||||||
Colon versus Rectum versus Ileocecal junction | 1.49 | 0.131 | 0.888–2.495 | |||
Histological type | ||||||
Adenocarcinoma versus Non-adenocarcinoma | 2.40 | 0.227 | 0.581–9.903 | |||
Tumor differentiation | ||||||
Well-Moderately versus Poorly | 0.23 | 0.001* | 0.117–0.449 | 0.30 | 0.004* | 0.134–0.689 |
Serum CEA level (ng/ml) | ||||||
≥15 versus <15 | 2.83 | 0.006* | 1.356–5.894 | 1.64 | 0.228 | 0.735–3.639 |
T (Primary tumor) | ||||||
T1 versus T2 versus T3 | 0.31 | 0.004* | 0.140–0.692 | 0.70 | 0.566 | 0.201–2.406 |
N (Lymph node metastasis) | ||||||
Positive versus Negative | 1.41 | 0.257 | 0.780–2.533 | |||
M (Distant metastasis) | ||||||
Positive versus Negative | 4.35 | 0.005* | 1.542–12.171 | 2.53 | 0.281 | 0.467–13.772 |
TNM stage | ||||||
Stage I versus Stage II versus Stage III versus Stage IV | 0.58 | 0.003* | 0.403–0.829 | 0.68 | 0.281 | 0.333–1.375 |