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Table 2 Univariate and multivariate analysis of prognostic factors in 112 CRC patients for overall survival

From: High Rab27A expression indicates favorable prognosis in CRC

  Univariate analysis Multivariate analysis
HR p value 95 % CI HR p value 95 % CI
Rab27A protein expression       
High versus Low or no 0.33 0.001* 0.181–0.616 0.36 0.012* 0.159–0.794
Gender       
Male versus Female 1.43 0.277 0.750–2.726    
Age (years)       
≥60 versus <60 1.16 0.642 0.618–2.184    
Tumor size (cm)       
≥5 versus <5 1.21 0.537 0.659–2.224    
Tumor location       
Colon versus Rectum versus Ileocecal junction 1.49 0.131 0.888–2.495    
Histological type       
Adenocarcinoma versus Non-adenocarcinoma 2.40 0.227 0.581–9.903    
Tumor differentiation       
Well-Moderately versus Poorly 0.23 0.001* 0.117–0.449 0.30 0.004* 0.134–0.689
Serum CEA level (ng/ml)       
≥15 versus <15 2.83 0.006* 1.356–5.894 1.64 0.228 0.735–3.639
T (Primary tumor)       
T1 versus T2 versus T3 0.31 0.004* 0.140–0.692 0.70 0.566 0.201–2.406
N (Lymph node metastasis)       
Positive versus Negative 1.41 0.257 0.780–2.533    
M (Distant metastasis)       
Positive versus Negative 4.35 0.005* 1.542–12.171 2.53 0.281 0.467–13.772
TNM stage       
Stage I versus Stage II versus Stage III versus Stage IV 0.58 0.003* 0.403–0.829 0.68 0.281 0.333–1.375
  1. *p < 0.05