Skip to main content

Table 4 Pathological features of confirmed IgG4-TIN, high-probability IgG4-TIN and both excluded groups in abundant plasma cells samples

From: Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis

  Abundant plasma cells samples High-probability IgG4-TIN
Pathological features High-probability IgG4-TIN (n = 12) Excluded (n = 43) P value 1 Confirmed IgG4-TIN (n = 2) Unconfirmed IgG4-TIN (n = 10) P Value 2
Inflammation infiltrating renal capsule 4 (33.3 ) 11 (25.6) 0.594 1 (50) 3 (30) 0.584
Inflammation infiltrating renal medulla 6 (50) 23 (53.5) 0.831 1 (50) 5 (50) 1.000
Isolated fibrosis 6 (50) 3 (7) 0.000 2 (100) 4 (40) 0.121
Collagenous fibrosis 8 (66.7) 7 (16.3) 0.001 2 (100) 6 (60) 0.273
Storiform fibrosis 3 (25) 1 (2.3) 0.007 2 (100) 1 (10) 0.007
Lymphoid follicles 2 (16.7) 1 (2.3) 0.053 0 (0) 2 (20) 0.488
Granulomatous lesions 1 (8.3) 0 (0) 0.056 0 (0) 1 (10) 0.640
Necrotizing angiitis 1 (8.3) 1 (2.3) 0.326 0 (0) 1 (10) 0.640
Obliterative phlebitis 0 (0) 0 (0) -- 0 (0) 0 (0) --
Eosinophil infiltration 8 (66.7) 18 (41.9) 0.128 2 (100) 6 (60) 0.273
Neutrophil infiltration 6 (50) 14 (32.6) 0.267 1 (50) 5 (50) 1.000
Tubulitis 9 (75) 16 (37.2) 0.020 2 (100) 7 (70) 0.371
Peritubular capillaritis 3 (25) 13 (30.2) 0.724 1 (50) 2 (20) 0.371
Tubular necrosis 8 (66.7) 18 (41.9) 0.128 0 (0) 8 (80) 0.091
TBM immune complex deposits 9 (75) 12 (27.9) 0.006 2 (100) 7 (70) 0.371
  1. Data are expressed as number (frequency); P value 1: High-probability IgG4-TIN compared to Excluded; P value 2: Confirmed IgG4-TIN compared to unconfirmed; --: no statistics.