Clinicopathologic features of plasmablastic lymphoma: Single-center series of 8 cases from Saudi Arabia

Diagnostic Pathology

Table 3 Differentiating PBL from other Neoplasms by Immunophenotyping

Parameter	PBL	Burkitt	Anaplastic DLBCL	PEL	ALK + DLBCL	PCM/Plasmacytoma	PLASMBLASTIC PCM/Plasmacytoma
Clinical presentation	frequently oral cavity	Often extranodal (jaws and orbits)	Wide variety of presentations	Involves body cavity	Wide variety of presentations	BM (Extramedulary in plasmacytoma)	BM (Extramedulary in plasmacytoma)
Immunocompetency	+/−	++	+++	+/−	+	++	++
Association with HIV	+++	++	++	+++	-	-	-
Association with HHV8	+/− (usually -)	-	-	+	-	-	-
LCA	+/−	+	+	+/−	+/−	+/−	+/−
B-Cell Markers
CD20	-	+	+	+/−	-	-	-
CD79a	+/−(usually -)	+	+	-	-	+/− (usually -)	+/− (usually -)
CD138	+	-	-	+	-	+	+
CD56	+/−(usually -)	Rare +	Rare +	Rare +	+/−	Usually +	Usually +
Ki67	High >70 %	High >90 %	High <90 %	High >80 %	High >80 %	Low	High >70 %
Other	BLIMP1+	CD10 +	BCL-6 Usually +	CD30 Usually +	ALK+	Serum M-spike CRAB	Serum M-spike CRAB

ISSN: 1746-1596