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Table 3 Differentiating PBL from other Neoplasms by Immunophenotyping

From: Clinicopathologic features of plasmablastic lymphoma: Single-center series of 8 cases from Saudi Arabia

Parameter PBL Burkitt Anaplastic DLBCL PEL ALK + DLBCL PCM/Plasmacytoma PLASMBLASTIC PCM/Plasmacytoma
Clinical presentation frequently oral cavity Often extranodal (jaws and orbits) Wide variety of presentations Involves body cavity Wide variety of presentations BM (Extramedulary in plasmacytoma) BM (Extramedulary in plasmacytoma)
Immunocompetency +/− ++ +++ +/− + ++ ++
Association with HIV +++ ++ ++ +++ - - -
Association with HHV8 +/− (usually -) - - + - - -
LCA +/− + + +/− +/− +/− +/−
B-Cell Markers        
CD20 - + + +/− - - -
CD79a +/−(usually -) + + - - +/− (usually -) +/− (usually -)
CD138 + - - + - + +
CD56 +/−(usually -) Rare + Rare + Rare + +/− Usually + Usually +
Ki67 High >70 % High >90 % High <90 % High >80 % High >80 % Low High >70 %
Other BLIMP1+ CD10 + BCL-6 Usually + CD30 Usually + ALK+ Serum M-spike CRAB Serum M-spike CRAB
  1. CRAB: hypercalcemia, kidney disease, anemia, and bone lytic lesions