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Table 1 Summary of the criteria to determine the nuclear grade for the DCIS classifications studied

From: Histopathological grading of breast ductal carcinoma In Situ: validation of a web-based survey through intra-observer reproducibility analysis

Holland
  High grade Intermediate grade Low grade
Nuclei Pleomorphic nuclei, anisonucleosis, irregular location, usually but not always large Slight pleomorphism, nuclei showing some variation in size, outline and spacing Monomorphic nuclei of uniform size, regular outline and spacing, usually small
Chromatin Vesicular Fine to coarse Uniform, fine
Nucleoli 1 or more Infrequent No nucleoli
Mitoses Often present Occasionally present Rare
Van Nuys
  High grade Intermediate grade Low grade
Nuclei diameter >2 RBC 1.5–2 RBC 1–1.5 RBC
Chromatin Vesicular Fine to coarse Uniform, fine
Nucleoli 1 or more Infrequent No nucleoli
Comedo-necrosis Present or absent Present Absent
Black Modified Nuclear Grade
  High grade Intermediate grade Low grade
Nuclei Pleomorphic nuclei, anisonucleosis, irregular location, usually but not always large Slight pleomorphism, nuclei showing some variation in size, outline and spacing Monomorphic nuclei of uniform size, regular outline and spacing, usually small
Nuclei diameter Up to 3 times the diameter of normal nuclei Up to 2 times the diameter of normal nuclei Same as normal nuclei
Chromatin Vesicular Fine to coarse Uniform, fine
Nucleoli 1 or more Infrequent No nucleoli
Mitoses Often present Occasionally present Rare