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Table 3 Correlations between clinicopathological and histopathological characteristics and ALCAM expression parameters in primary tumors and nodal metastases

From: Prognostic significance of ALCAM (CD166/MEMD) expression in cutaneous melanoma patients

  ALCAM expression – primary tumor ALCAM expression – nodal metastasis
Clinicopathological parameters %a Intb IRSc %a Intb IRSc
pTad 0.0001 0.245 0.016 0.257 0.977 0.659
pNe 0.211 0.228 0.805 0.439 0.952 0.870
Distant metastasese 0.145 0.886 0.152 0.257 0.596 0.749
Recurrencee 0.161 0.082 0.705 0.705 0.906 0.669
Aged 0.368 0.555 0.303 0.467 0.866 0.793
Gendere 0.452 0.596 0.699 0.166 0.724 0.699
Primary tumor locationf 0.412 0.470 0.586 0.779 0.864 0.992
Histopathological parameters % Int IRS % Int IRS
Breslow thicknessd 0.003 0.342 0.008 0.340 0.865 0.744
Clark leveld 0.026 0.912 0.001 0.032 0.598 0.400
Growth phasee 0.422 0.714 0.568 100 % vertical growth phase
Histologic typef 0.523 0.082 0.749 0.529 0.906 0.709
Mitotic rated 0.050 0.163 0.536 0.834 0.825 0.976
Ulceratione 0.035 0.795 0.086 0.564 0.840 0.625
Lymphangioinvasione 0.523 0.379 0.480 0.439 0.147 0.274
Microsatellitosise 0.249 0.381 0.616 0.439 0.717 0.444
Tumor-infiltrating lymphocytes (TILs)f 0.010 0.389 0.451 0.967 0.359 0.549
Tumor regressione 0.761 0.364 0.771 100 % without regression
  1. aPercentage of ALCAM-positive melanoma cells (0–4 points)
  2. bIntenisty of immunohistochemical reaction (0–3 points)
  3. cImmunoReactive Score (product of the scores for the percentage of positive cells and intensity of reaction (0–12 points)
  4. d P value of Spearman rank correlation
  5. e P value of Mann-Whitney’s U test
  6. f P value of Kruskal-Wallis test
  7. Statistically significant results (P < 0.05) are in bold font