Fig. 2

Histologic picture and immunohistochemistry panel of a right cervical lymph node. The node structure was disrupted with effacement by diffuse distribution of pleomorphic neoplastic cells (×200, H&E) (a), most of which were large, and round to oval in shape. Some neoplastic giant cells were observed. The cytoplasm was usually abundant, and the nuclei were generally large and round with a prominent nucleolus. The chromatin was hyperchromatic, coarse, and granular. Mitotic figures were easily observed. Remaining lymphoid follicles were found (×400, H&E) (b). IHC phenotype of neoplastic cells show positive for CD68 (c), MAC387 (d), lysozyme (e), but negative for myeloperoxidase (f)