Table 1 Cases of renal-type clear cell carcinoma of the prostate in literature
From: Renal-type clear cell carcinoma of the prostate: a diagnostic challenge
S.No. | Author (Year)[Ref] | Age (years) | Serum PSA at diagnosis | Type of specimen | Microscopy | Special stain | Immunohistochemistry | Outcome (Follow-up duration) |
|---|---|---|---|---|---|---|---|---|
1. | Singh et al. (2003) [2] | 73 | 1.5 mg/dl | TURP followed by radical cystoprostatectomy + pelvic lymph node dissection | Clear cell carcinoma similar to RCC and typical prostatic adenocarcinoma (Gleason’s score 3 + 3) | Mucicarmine staining for intracytoplasmic mucin: negative | Positive: Vimentin, EMA, LMWCK and CD10 | No evidence of disease (7 months) |
Negative: PSA, PSAP, S-100, HMB-45, Broad spectrum cytokeratin (AE1/AE3), CK7, CK20, HMWCK, CA-125, CEA, ER and PR | ||||||||
2. | Pal & Chowdhury (2007) [3] | 64 | 2.1 ng/L | TURP | Clear cell carcinoma similar to RCC | Mucicarmine staining for intracytoplasmic mucin : negative | Positive: Pancytokeratin, Vimentin and EMA | No evidence of pelvic lymph node metastasis (12 months) |
Negative: PSA, PSAP and HMWCK | ||||||||
3. | Permi et al. (2011) [4] | 64 | 82 ng/ml | TURP followed by radical cystoprostatectomy + pelvic lymph node dissection | Clear cell carcinoma similar to RCC | Not done | Not done | No evidence of recurrence (12 months) |
4. | Wang et al. (2015) [5] | 64 | 10.2 ng/ml | TURP | Clear cell carcinoma similar to RCC and typical prostatic adenocarcinoma (Gleason’s score 4 + 4) | Not done | Positive: LMWCK, Vimentin, EMA, CD10, PSAP and AMACR | Death due to multiorgan failure (6 months) |
Negative: HMWCK, CEA, Broad spectrum cytokeratin and PAX8 | ||||||||
5. | Present case (2015) | 72 | 65.2 ng/ml | Radical prostatectomy and pelvic lymphadenectomy | Clear cell carcinoma similar to RCC and typical prostatic acinar adenocarcinoma (Gleason’s score 4 + 4) | Periodic acid Schiff for intracytoplasmic droplets: Positive | Positive: Pancytokeratin, EMA, CD10, Vimentin and AMACR | Alive with controlled serum PSA levels (20 months) |
Negative: HMWCK (34βE12), CK7, PSA and PAX8 |