Table 1 Clinicopathological features of Merkel cell carcinoma
From: Unexpected maspin immunoreactivity in Merkel cell carcinoma
Case no | Age (years) | Location | Sex | Size (mm) | Ulceration | Stage | Depth of invasion | Mitotic rate (per 10 HPF) | Positive IHC markers | Negative IHC markers |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 67 | Frontal region | Male | 17×17×8 | Present | pT1 | Subcutaneous adipose tissue | 30 | AE1/AE3 keratin, keratin 20, EMA, Chromogranin, Synaptophysin, NSE, CD56, CD99, bcl-2, maspin | Vimentin, Keratin 7, S-100 protein, desmin, CEA, CD20, CD3, DOG-1, HMB45, E-cadherin, CD3, CD20, CD10, TTF-1 |
2 | 55 | Right thigh | Female | 10×10×5 | Absent | pT1 | Subcutaneous adipose tissue | 15 | keratin20, Chromogranin, Synaptophysin, NSE, CD99, bcl-2 | Vimentin, Keratin 7, S-100 protein, desmin, CEA, CD20, CD3, DOG-1, HMB45, E-cadherin, CD3, CD20, CD10, TTF-1, maspin |
3 | 63 | Thoracic region | Female | 12×12×12 | Absent | pT1 | Subcutaneous adipose tissue | 3 | AE1/AE3 keratin, keratin 20, EMA, Chromogranin, Synaptophysin, NSE, CD56, CD99, bcl-2, maspin | Vimentin, Keratin 7, S-100 protein, desmin, CEA, CD20, CD3, DOG-1, HMB45, E-cadherin, CD3, CD20, CD10, TTF-1 |