Table 2 aCGH copy number alterations identified in GBM patient
From: Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Gene/Region | Chromosome Band | Copy Number Change | Nucleotides (GRCh37//hg19) |
|---|---|---|---|
MYCL1 | 1p34.2 | -- | -- |
CDKN2C | 1p33 | -- | -- |
PIK3C2B | 1q32.1 | -- | |
MDM4 | 1q32.1 | -- | -- |
AKT3 | 1q44 | -- | |
MYCN | 2p24.3 | -- | -- |
PIK3CA | 3q26.32 | -- | |
SOX2 | 3q26.33 | -- | -- |
FGFR3 | 4p16.3 | -- | |
PDGFRA | 4q12 | 550 kb focal gain | chr4:55,072,465–55,622,596 |
TERT | 5p15.33 | -- | |
MYB | 6q23.3 | -- | -- |
PARK2 | 6q26 | -- | |
QKI | 6q26 | -- | -- |
EGFR | 7p11.2 | -- | |
EGFRvIII | 7p11.2 | -- | -- |
CDK6 | 7q21.2 | -- | |
MET | 7q31.2 | -- | -- |
BRAF | 7q34 | -- | |
FGFR1 | 8p11 23-p11.22 | -- | -- |
MYBL1 | 8q13.1 | -- | |
MYC | 8q24.21 | -- | -- |
CDKN2A | 9p21.3 | 38.5 Mb single copy gain | chr9:204,104–38,731,432 |
NTRK2 | 9q21.32-q21.33 | 1.3 Mb focal gain | chr9:86,840,129–88,134,100 |
NTRK2 | 9q21.32-q21.33 | 159 kb intragenic amplification | chr9:87,344,078–87,503,027 |
PTEN | 10q23.31 | 82.6 Mb single copy loss | chr10:52,805,936–135,435,714 |
FGFR2 | 10q26.13 | 82.6 Mb single copy loss | chr10:52,805,936–135,435,714 |
CCND2 | 12p13.32 | 34.6 Mb single copy loss | chr12:163,593–34,756,209 |
NAB2 | 12q13.3 | 37 kb amplification | chr12:57,484,461 –57,521,151 |
STAT6 | 12q13.3 | 37 kb amplification | chr12:57,484,461 –57,521,151 |
CDK4 | 12q14.1 | 131 kb amplification | chr12:58,034,214–58,165,540 |
MDM2 | 12q15 | 95.3 Mb single copy loss | chr12:38,448,667–133,779,076 |
RB1 | 13q14.2 | Single copy loss via monosomy 13 | chr13:19,296,544–115,105,297 |
TP53 | 17p13.1 | 19.5 Mb single copy loss | chr17:47,546–19,536,368 |
NF1 | 17q11.2 | -- | |
SMARCB1/INI1 | 22q11.23 | Single copy loss via monosomy 22 | chr22:16,133,474–51,219,009 |
NF2 | 22q12.2 | Single copy loss via monosomy 22 | chr22:16,133,474–51,219,009 |
1p- | n/a | -- | -- |
4p- | n/a | -- | |
Monosomy 6 | n/a | -- | |
6q- | n/a | -- | |
Polysomy 7 | n/a | -- | |
7p- | n/a | -- | |
Monosomy 10 | n/a | -- | |
10q- | n/a | 82.6 Mb single copy loss | chr10:52,805,936–135,435,714 |
11p- | n/a | -- | -- |
Monosomy 14 | n/a | -- | |
idic(17p11.2) | n/a | -- | |
18q- | n/a | -- | |
19q- | n/a | -- | |
Monosomy 22 | n/a | Detected | chr22:16,133,474–51,219,009 |